SR9011
| Price | $9.9 | $17337 |
| Package | 1g | 1000g |
| Min. Order: | 1g |
| Supply Ability: | 100kg |
| Update Time: | 2024-09-03 |
Product Details
| Product Name: SR9011 | CAS No.: 1379686-29-9 |
| Min. Order: 1g | Purity: 99% |
| Supply Ability: 100kg | Release date: 2024/09/03 |
| SR9011 Usage And Synthesis | |
| Biochem/physiol Actions | SR9011 is a potent nuclear receptor REV-ERB agonist (EC50 of REV-ERBα- and REV-ERBβ-dependent repressor activity = 790 and 560 nM, respectively, by cell-based reporter assay) that stimulates REV-ERB-dependent target genes suppression both in cultures in vitro and in mice in vivo (100 mg/kg i.p., b.i.d.) without activity toward a panel of 46 other nuclear receptors. SR9011 is shown to modulate circadian behavior by suppressing the transcription factors BMAL1 (brain and muscle ARNT-like protein 1) and CLOCK (circadian locomotor output cycles kaput) as well as induce energy expenditure and weight loss by regulating genes involved in lipid and glucose metabolism in mice in vivo with good bioavailabiilty (plasma conc. = 0.53 and 15.3 μM 2 hr post 10 or 100 mg/kg i.p. dosage; brain conc. = 0.24 μM 2 hr post 10 mg/kg i.p.), while its structure analog GSK4112 shows no plasma exposure. |
| Uses | SR 9011 is a synthetic REV-ERBα/β agonist with activity in vivo. It is a lead compound for a new class of cancer drugs associated with the body’s circadian clock. |
| Application | SR9011 has been used as a nuclear receptor subfamily 1 group D member 1 (NR1D1) receptor agonist: to study its effects on microglial immune-metabolism to study its effects on insulin secretion from human type 2 diabetes islet cells to study its effects on thyroid-stimulating hormone β (TSHβ) gene expression |
Advantage:
1. Our company is a professional production leading factory in China in pharmaceutical area of many years. Delivery areas of our products:US, UK, Canada, Australia, Brazil, Russia, Portugal, Latvia, Switzerland, Iceland, Ukraine, Germany, France, Netherlands, Belgium, Peru, Sweden, New Zealand, the Czech Republic, Lithuania, Ireland, Tunisia, Mexico, Greece, Puerto Rico, Thailand, Israel and so on.
Payment method: T/T, Western union, Moneygram.
2. Discreet package.The packing suits you best would be choosen to cross customs safely. Or if you have your own ideal way, it could be also take into consideration.
3. Top quality. High quality guarenteed, once any problem is found, the package would be reshipped for you.
4. Security Shipping: Shipping by express (FedEx,UPS,DHL,EMS), by air.The most professional forwarder would be recommanded for you.
5. We have stock, so we can delivery quickly at the very day when receive the payment.
6. Warm after-sale service for you 24/7. Any of your question would be solved for the first as soon as possible.
7. A discount would be given when you make a large order.
Company Profile Introduction
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China- Since: 2023-03-16
- Address: Room 21, Floor 7, Building 3, SBI Chuangye Street, Dongxin Road, Donghu New Technology Development Z