Stavudine NEW
| Price | $33 | $47 | $65 |
| Package | 50mg | 100mg | 200mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-17 |
Product Details
| Product Name: Stavudine | CAS No.: 3056-17-5 |
| Purity: 99.15% | Supply Ability: 10g |
| Release date: 2024/11/17 |
Product Introduction
Bioactivity
| 名称 | Stavudine |
| 描述 | Stavudine (BMY-27857), a nucleoside reverse transcriptase inhibitor analog of thymidine, has activity against HIV. |
| 体外活性 | In lean mice, Stavudine (500 mg/kg/day) reduces mitochondrial DNA in the liver and muscle, inducing ketoacidosis during fasting periods. In obese mice, Stavudine (500 mg/kg/day) depletes mtDNA in White Adipose Tissue (WAT). |
| 体内活性 | Stavudine reduces lipid content and influences the expression of lipid metabolism markers, such as C/EBPα, peroxisome proliferator-activated receptor γ, adipocyte lipid-binding protein 2, fatty acid synthase, and acetyl-CoA carboxylase. In 3T3-F442A cells, Stavudine induces apoptosis and reduces both lipid content and viability in 3T3-L1 adipocytes. Furthermore, in peripheral blood mononuclear cells (PBMC), Stavudine inhibits the production of p24 antigen by HIV-1, with an effective dose range of 0.04 μM to 0.2 μM (ED50 = 0.04 μM-0.2 μM). |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 50 mg/mL (223.01 mM) H2O : 22.4 mg/mL (100 mM) |
| 关键字 | BMY27857 | nucleoside | inflammasome | Autophagy | NSC-163661 | mtDNA | Apoptosis | inhibit | HIV | NOD-like Receptor (NLR) | antiretroviral | analogue | Stavudine | Inhibitor | Reverse Transcriptase | Human immunodeficiency virus | Amyloid-β | NSC163661 | BMY 27857 | Nucleoside Antimetabolite/Analog |
| 相关产品 | Emtricitabine | Sodium 4-phenylbutyrate | Hydroxychloroquine | Guanidine hydrochloride | Lamivudine | Tributyrin | Paeonol | Naringin |
| 相关库 | 经典已知活性库 | EMA 上市药物库 | 抗癌临床化合物库 | 药物功能重定位化合物库 | 抗病毒库 | 抑制剂库 | 抗癌上市药物库 | FDA 上市药物库 | 抗衰老化合物库 | 抗癌药物库 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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