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Postion:Product Catalog >API>Hormones and the Endocrine System>Erectile Dysfunction Treatment>Tadalafil
Tadalafil
  • Tadalafil

Tadalafil NEW

Price $2
Package 1kg
Min. Order: 1kg
Supply Ability: 1200KG/M
Update Time: 2024-07-22

Product Details

Product Name: Tadalafil CAS No.: 171596-29-5
EC-No.: 687-782-2 Min. Order: 1kg
Purity: 99% Supply Ability: 1200KG/M
Release date: 2024/07/22

Chemistry: Tadalafil is an annulated 2,5-diketopiperazine.It is also a 1,2,3,4-tetrahydro-β-carboline.Tadalafil can be synthesized starting from (D)-tryptophan methyl ester and piperonal via a PictetSpengler reaction. This is followed by condensations with chloroacetyl chloride and methylamine to complete the diketopiperazine ring.

Medical uses: Tadalafil is used to treat erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension.In the US, tadalafil (as Cialis) is indicated for the treatment of erectile dysfunction and the signs and symptoms of benign prostatic hyperplasia; and (as Adcirca) for the treatment of pulmonary arterial hypertension to improve exercise ability.

Mechanism of action: Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and the smooth muscle of the corpus cavernosum. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cyclic guanosine monophosphate (more commonly known as cyclic GMP or cGMP) in smooth muscle cells.cGMP relaxes smooth muscle and increases blood flow to the corpus cavernosum.The inhibition of phosphodiesterase type 5 (PDE5) enhances erectile function by increasing the amount of cGMP. Tadalafil (and sildenafil and vardenafil) inhibits PDE5. However, because sexual stimulation is required to initiate the local penile release of nitric oxide, tadalafil's inhibition of PDE5 will have no effect without sexual stimulation.


Company Profile Introduction

Founded in 2012, Jinan Million Pharmaceutical Co., Ltd (Jinan Milin Pharmaceutical Co., Ltd) is a modern pharmaceutical enterprise guided by innovation. Million pharm has excellent research and development capabilities and complete industrial bases with international quality management system. It is dedicated to the research, development, production and customization of pharmaceuticals and advanced pharmaceutical intermediates. Jinan Million Pharmaceutical Co., Ltd has been focusing on the research of Cerebro-cardiovascular drugs, Central nervous system drugs, Anti-cancer drugs, Anti-aging drugs, Antibacterial drugs and others for more than 10 years; the products are: Apixabn, Lurasidon, Votioxitin, Edoxabn, Loxo-292/Selpercatinib, β-nicotinamid mononucleotid, Indacaterl and their intermediates. Million has established long-term friendly cooperative relationship with customers in Egypt, Japan, India, and Russia relying on great quality and cost-competitive products. Jinan Million Pharmaceutical Co., Ltd has a 1,500㎡ R&D center in the Zhongguancun E Valley (Qihe) Incubator, equipped with complete test equipment, such as high-performance liquid chromatography, nuclear magnetic resonance spectrometer, liquid chromatography mass spectrometer, automatic polarimeter, etc., which can meet the needs of various laboratory scale tests in different conditions. The pilot workshop is equipped with 50L and 100L glass reactors, high and low temperature equipment, etc., which can support organic chemical reactions at -100°C or 200°C. In addition, Million has a production site in Linyi city with many independent production lines, such as: production line of Apixabn intermediate 20 tons/year, production line of Lurasidon intermediate 10 tons/year, which can meet the commercial production of various products. The technical team is composed of high-level talents in major of pharmacy, bio-pharmaceutical or chemical synthesis, of which 10% has doctor’s degree and 15% has mas

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  • Since: 2012-04-12
  • Address: Lianhecaifu Square, No2177, Tianchen Road, Gaoxin District, Jinan City, Shandong Provi
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