Taurodeoxycholic acid NEW
| Price | $56 | $118 | $171 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2024-11-13 |
Product Details
| Product Name: Taurodeoxycholic acid | CAS No.: 516-50-7 |
| Purity: 99.22% | Supply Ability: 10g |
| Release date: 2024/11/13 |
Product Introduction
Bioactivity
| 名称 | Taurodeoxycholic acid |
| 描述 | Taurodeoxycholic acid (Taurodeoxychloic acid) is a bile acid taurine conjugate of deoxycholic acid, a human metabolite that stabilizes mitochondrial membranes and reduces the formation of free radicals.Taurodeoxycholic acid inhibits apoptosis by blocking calcium-mediated apoptotic pathways and by activation of caspase-12. Taurodeoxycholic acid has neuroprotective activity and has been used to study 3-nitropropionic acid-induced or stabilized hereditary Huntington's chorea (HD). |
| 体外活性 | Taurodeoxycholic acid (50, 100 μM; 4 h) increases oligonuclear DNA cleavage and nuclear apoptosis in primary human hepatocytes.[1] Taurodeoxycholic acid (400 μM; 18-24 h) increases DNA fragmentation and PARP cleavage and induces apoptosis in human liver-derived Huh7 cells.[2] |
| 体内活性 | Taurodeoxycholic acid (50 mg/kg; i.p.; once daily for 34 days; Huntington's disease model in mice) prevents neuropathology and associated behavioral deficits in a rat model of Huntington's disease (HD).[3] Taurodeoxycholic acid (500 mg/kg; subcutaneous injection; every 3 days for 7 weeks; Huntington's disease model in mice) resulted in a significant reduction in striatal neuropathology in R6/2 transgenic HD mice.[4] |
| 存储条件 | store at low temperature | Shipping with blue ice. |
| 溶解度 | DMSO : 50 mg/mL, (100 mMd）, Sonication is recommended. |
| 关键字 | Taurodeoxycholic acid |
| 相关产品 | Stavudine | 5-Fluorouracil | Myricetin | Sodium 4-phenylbutyrate | L-Ascorbic acid | Dextran sulfate sodium salt (MW 4500-5500) | Metronidazole | Sorafenib | Tributyrin |
| 相关库 | 经典已知活性库 | 疼痛相关化合物库 | 膜蛋白靶向化合物库 | 天然产物库 | 微生物天然产物库 | 神经保护化合物库 | 高通量筛选天然产物库 | 已知活性化合物库 | 肠道微生物代谢化合物库 | 离子通道库 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
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