Tauroursodeoxycholic acid NEW

Tauroursodeoxycholic acid CAS:14605-22-2 With high Purity

Product Name:Tauroursodeoxycholic acid

Synonyms：ursodeoxycholyltaurine;yl)amino)-;3a,7b-Dihydroxy-5b-cholan-24-oic Acid N-(2-Sulfoethyl)amide;Ursodeoxycholyltaurin;3α,7β-dihydroxy-5β-cholan-24-oic acid n-(2-sulfoethyl)amide;TUDCA Soduim Salt;TAUROURSODEOXYCHOLIC ACID DIHYDRATE: 90%;tauroursodeoxycholic acid sodium

CAS:14605-22-2

MF:C26H45NO6S

MW:499.7

EINECS:  1308068-626-2

Melting point：173-175°C

density：1.216±0.06 g/cm3(Predicted)

refractive index：46 ° (C=1, EtOH)

storage temp.：15-25℃

solubility：Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 20 mg/ml with warming)

Stability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

Chemical Properties：Tauroursodeoxycholic acid is an off-White Solid. It is an ambiphilic bile acid. It is mainly found in black bear bile, which is the signature active ingredient in bear bile. It has antispasmodic, anticonvulsant, anti-inflammatory and gallstone dissolving effects.

Description   

Tauroursodeoxycholic acid (TUDCA) is a hydrophilic bile acid synthesized in hepatocytes by the conjugation of ursodeoxycholic acid (UDCA) with the amino acid taurine. UDCA, which is made by gut bacteria, is FDAapproved in the United States for the treatment of certain cholestatic liver diseases. Humans make TUDCA to some extent, but it is found in copious amounts in the bile of bears. TUDCA is a classic inhibitor of endoplasmic reticulum (ER) stress. Reduces ER stress and adipose tissue inflammation in a mouse model of high fat diet-induced obesity. Blocks ER stress-induced NLRP3 inflammasome activation and hepatocyte death. Attenuates amyloid precursor protein processing and amyloid-β deposition in APP/PS1 mouse model.