Product Details
| Product Name:
TBCA |
CAS No.:
934358-00-6 |
| Purity:
99.31% |
Supply Ability:
10g |
| Release date:
2024/11/11 |
Product Introduction
Bioactivity
| 名称 | TBCA |
| 描述 | TBCA (Casein Kinase II Inhibitor III, TBCA) is a highly selective CK2 (casein kinase II) inhibitor, IC50 = 110 nM, Ki = 77 nM. TBCA shows selectivity for CK2 over CK1, DYRK1A and a panel of 27 other kinases. |
| 体外活性 | TBCA inhibits CK2 double mutant (Val66 Ile174) with an IC50 of 0.68 μM. TBCA (0-100 μM; 24 hours) shows a drastic effect on Jurkat cells viability [1]. TBCA dose-dependently inhibits platelet aggregation and secretion induced by various agonists including CRP, 2-MeSADP, AYPGKF and SFLLRN. TBCA also inhibits phosphorylation of PDK1, Akt, and GSK3β induced by AYPGKF[2]. |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 45 mg/mL (97.04 mM), Sonication is recommended.
|
| 关键字 | TBCA |
| 相关产品 | CK2-IN-4 | Ellagic acid | Casein Kinase II Inhibitor IV | Silmitasertib | CK2α-IN-1 | Emodin | LY-364947 | AS-252424 | TA-01 | CK2/ERK8-IN-1 | Casein kinase 1δ-IN-6 | LY294002 |
| 相关库 | 高选择性抑制剂库 | 经典已知活性库 | 激酶抑制剂库 | 抑制剂库 | 已知活性化合物库 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States