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Tegoprazan Basic information

Drug Approval Medical efficacy

Product Name: Tegoprazan

Synonyms: 7-[[(4S)-5,7-difluoro-3,4-dihydro-2H-chromen-4-yl]oxy]-N,N,2-trimethyl-3H-benzimidazole-5-carboxamide;CJ 12420;RQ-00000004;RQ-4;1H-Benzimidazole-5-carboxamide, 7-[[(4S)-5,7-difluoro-3,4-dihydro-2H-1-benzopyran-4-yl]oxy]-N,N,2-trimethyl-;7-[[(4S)-5,7-difluoro-3,4-dihydro-2H-1-benzopyran-4-yl]oxy]-N,N,2-trimethyl-1H-benzimidazole-5-carboxamide;Tegoprazan Emixustat HCL Hydrochloride;Tegoprazan

CAS: 942195-55-3

MF: C20H19F2N3O3

MW: 387.38

EINECS:

Product Categories: Tegoprazan;API

Mol File: 942195-55-3.mol

Tegoprazan Structure

Tegoprazan Chemical Properties

Boiling point 596.5±50.0 °C(Predicted)

density 1.371±0.06 g/cm3(Predicted)

storage temp. Store at -20°C

solubility DMSO: soluble

form A solid

pka 9.73±0.30(Predicted)

Safety Information

MSDS Information

Tegoprazan Usage And Synthesis

Drug Approval Tegoprazan was approved by the Ministry of Food and Drug Safety (MFDS) for marketing in July 2018 for the treatment of gastroesophageal reflux disease and erosive esophagitis. Tegoprazan was originally developed by Pfizer. In 2008, it was licensed to RaQualiaPharma (separated from Pfizer) for joint development. In 2014, Tegoprazan was licensed to CJHealthCare by RaQualiaPharma. Finally, CJHealthCare was successfully developed and marketed in Korea. The drug was first marketed in South Korea.

Medical efficacy Tegoprazan is medicine for treating gastroesophageal reflux disease and erosive esophagitis. Proton pump hydrogen ion/potassium ion exchange ATPase is the main pharmacological target for the treatment of gastric acid-related diseases. Potassium-competitive acid blocker (P-CAB) can inhibit gastric acid secretion by competitively binding to K+ with H+/K+-ATPase. Research finds that Tegoprazan is such a potassium-competitive acid blocker and is considered to be the most advanced drug for treating gastroesophageal reflux disease, because proton pump inhibitors are the most commonly used drugs for treating gastroesophageal reflux disease.

Uses Tegoprazan is used for remedying and treating nocturnal acid breakthrough symptoms, such as GERD, ulcer, Barrett''s esophagus, and heartburn.