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Postion:Product Catalog >API>Synthetic Anti-infective Drugs>Antiviral drugs>Tenofovir
Tenofovir
  • Tenofovir
  • Tenofovir
  • Tenofovir
  • Tenofovir
  • Tenofovir

Tenofovir

Price Get Latest Price
Package 1Kg/Bag 25Kg/Bag 100Kg/Bag
Min. Order: 0.1Kg/Bag
Supply Ability: 20 tons
Update Time: 2024-12-20

Product Details

Product Name: Tenofovir CAS No.: 147127-20-6
EC-No.: 604-571-2 Min. Order: 0.1Kg/Bag
Purity: 99% min, GMP Supply Ability: 20 tons
Release date: 2024/12/20

Product Information

API Powder 99% Tenofovir CAS 147127-20-6

Tenofovir, chemical name R-9-(2-phosphate methoxypropyl) adenine (PMPA), molecular formula C9H14N5O4P, is a nucleotide reverse transcriptase inhibitor.
Nucleotide analogs reverse transcriptase inhibitors can block HIV replication. Combined with other antiretroviral drugs to treat HIV-1 infection. Used in the treatment of AIDS.

COA
Melting point 276-280°C
alpha D +21° (c = 1 in 0.1M HCl)
Boiling point 616.1±65.0 °C(Predicted)
density 1.79±0.1 g/cm3(Predicted)
storage temp. -20°C
pka2.36±0.10(Predicted)
form powder
color white to beige
optical activity[α]/D -20 to -26°, c = 0.5 in 1 M HCl
Water Solubility 13.4 mg/mL (25 ºC)
Merck 14,9146
CAS DataBase Reference147127-20-6(CAS DataBase Reference)
COA

Items of analysis

Specification

Results

Appearance

White powder or off-white powder

White Powder

Identification

Must conform to reference standard

Conforms

Water

NMT3.0%

1.53%

Residue on ignition

NMT2.0%

1.07%

Specific Rotation

-19.0°~-23.0°

-22.5°

Sulphated ash

≤1.5%

0.27%

Single impurity

≤1.0%

0.29%

Total impurity

≤3.0%

1.11%

Assay(Titrimetry)

98.0%-102%

99.60%

9-Propenyl adenine

≤100ppm

Conforms

PMPA Monoester Impurity

≤1.5%

0.35%

Conclusion

Qualified

Tenofovir Usage And Synthesis

1. Antiviral drugs, Tenofovir is an acyclic nucleoside antiviral reverse transcriptase inhibitor. The active substance is Tenofovir disoproxil, while tenofovir is a prodrug that is used because of its better absorption in the gut.

2. Tenofovir can inhibit viral polymerase through direct competitively combine with natural deoxyribose or by insertion to terminate chain of human DNA. It is the first nucleotide analogs to treat HIV-1 infection that approved by the US Food and Drug Administration (FDA).

3. Tenofovir is a main medicine in AIDS cocktail therapy, researches has shown that it can effectively improve the monkeys` ability on prevention of immunodeficiency virus (similar to the human AIDS virus).

Article illustration



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Company Profile Introduction

Sinoway Industrial co., ltd. was established in 1987 in Xiamen, China, and now has been a leading group specialized in research, development, custom manufacturing and trading of pharmaceutical intermediates, APIs, health and food supplements, cosmetic raw materials, herbal extracts, polypeptides and prostaglandin derivatives, etc.. We have passed ISO9001:2015. With qualified products, competitive price and excellent service, we have received great reputation of our customers from all over the world, including Southeast Asia, Europe, North America, South America, Middle East and other countries. We have over 20 years good partners in Japan、Korea and Switzerland. Sinoway has a professional R&D team. We have built close cooperative relationships with many research institutes and universities in China. Moreover, Sinoway combines market analysis with technology, providing new business trends to our clients. In addition, we have very close cooperation relationships with many Chinese pharmaceutical factories. These pharmaceutical manufacturers have GMP regulated workshops, advanced production and testing equipments, first-class QC labs and a production team with rich experience. We can supply various Active Pharmaceutical Ingredients and finished products which meet EP/USP/BP standards. Chinese GMP, EU-GMP, COS/CEP certificates with DMF documents are available, and many products have been approved by FDA. We believe that quality and innovation are vital for an enterprise. Adhering to the business philosophy of integrity and win-win cooperation, Sinoway is looking forward to have a bright future with you together.

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