Tetracaine hydrochloride NEW

Tetracaine hydrochloride is a highly effective local anesthetic that can block nerve function reversibly. It is used in infiltration anesthesia, nerve block anesthesia, epidural anesthesia, etc. Compared with procaine, tetracaine has remarkable local anesthetic effect and has been widely used in clinic. It is found that the synthesis of p-butylaminobenzoic acid is the key step in the synthesis of tetracaine hydrochloride, which always has the disadvantages of unstable raw materials or low yield. Scientists have improved and improved this, in 1981 proposed to synthesize p-butylaminobenzoic acid by alkylation of p-aminobenzoic acid with 1-bromobutane, but because it can not avoid the generation of double butylated by-products, and the nature of the raw material itself is unstable, making this route is not suitable for industrial production.

Drug interaction: 

1. This drug can enhance the nerve blocking effect of cisatracurium, and the dosage of the latter should be reduced when combined. 2. In combination with adrenaline, blood vessels can be constricted, blood flow is reduced, drug absorption is slowed down, and the duration of action is prolonged. However, they are not suitable for patients with heart disease, hypertension, hyperthyroidism and peripheral vascular disease. 3. Hyaluronidase can effectively increase the diffusion of this drug, accelerate the effect of anesthesia, reduce local swelling, and prevent the formation of hematoma, however, hyaluronidase can also accelerate the absorption of this drug, resulting in increased toxic reactions of this drug. 4. This drug is a derivative of p-aminobenzoic acid (PABA), and sulfonamides play an antibacterial role by inhibiting PABA of bacteria. When this drug is combined with sulfonamides, the antibacterial effect of the latter will be inhibited, so the two are not suitable for use. 5. This medicine is acidic and should not be mixed with alkaline liquid. Even if it is an acidic drug, the dissociation value of the drug can be affected due to the difference in pH, so that the effect is reduced, or the onset time is delayed. 6. Iodine preparation can cause the precipitation of this drug, so the injection site of this drug can not use iodine.

Application:

Used as a local anesthetic.