![Thiourea, N-(4-methoxyphenyl)-N'-[5-(5-nitro-2-furanyl)-1,3,4-thiadiazol-2-yl]-](/ProductImageEN/2024-05/Large/3053c0fb-2403-4d39-8eae-2ea66c10b2ed.jpg)
Thiourea, N-(4-methoxyphenyl)-N'-[5-(5-nitro-2-furanyl)-1,3,4-thiadiazol-2-yl]- NEW
Price | $6 |
Package | 1kg |
Min. Order: | 1kg |
Supply Ability: | 200t |
Update Time: | 2024-08-22 |
Product Details
Product Name: Thiourea, N-(4-methoxyphenyl)-N'-[5-(5-nitro-2-furanyl)-1,3,4-thiadiazol-2-yl]- | CAS No.: 2413974-52-2 |
EC-No.: 974-152-2 | Min. Order: 1kg |
Purity: 99+ | Supply Ability: 200t |
Release date: 2024/08/22 |
Common Name | MT-802 | ||
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CAS Number | 2231744-29-7 | Molecular Weight | 787.82 |
Density | N/A | Boiling Point | N/A |
Molecular Formula | C41H41N9O8 | Melting Point | N/A |
MSDS | N/A | Flash Point | N/A |
Name | MT-802 |
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Description | MT-802 is a potent BTK degrader based on PROTAC technology, with a DC50 of 1 nM. MT-802 has potential to treat C481S mutant chronic lymphocytic leukemia (CLL)[1]. |
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Related Catalog | Research Areas >> Cancer Research Areas >> Inflammation/Immunology Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk Signaling Pathways >> PROTAC >> PROTAC |
Target | DC50: 1 nM (BTK)[1]. |
In Vitro | MT-802 degrades BTK with a DC50 of 9.1 nM with maximal degradation being observed by 250 nM[1]. |
References | [1]. Buhimschi AD, et al. Targeting the C481S Ibrutinib-Resistance Mutation in Bruton's Tyrosine Kinase Using PROTAC-Mediated Degradation. Biochemistry. 2018 Jul 3;57(26):3564-3575. |
Molecular Formula | C41H41N9O8 |
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Molecular Weight | 787.82 |
Storage condition | -20°C |
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- Address: Room 815, Block A, Yiyuan International Building, No.319, Xinyi Road, Zhengzhou, Henan Pilot Free Tr
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