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Thiourea, N-(4-methoxyphenyl)-N'-[5-(5-nitro-2-furanyl)-1,3,4-thiadiazol-2-yl]- NEW
| Price | $6 |
| Package | 1kg |
| Min. Order: | 1kg |
| Supply Ability: | 200t |
| Update Time: | 2024-08-22 |
Product Details
| Product Name: Thiourea, N-(4-methoxyphenyl)-N'-[5-(5-nitro-2-furanyl)-1,3,4-thiadiazol-2-yl]- | CAS No.: 2413974-52-2 |
| EC-No.: 974-152-2 | Min. Order: 1kg |
| Purity: 99+ | Supply Ability: 200t |
| Release date: 2024/08/22 |
| Common Name | MT-802 | ||
|---|---|---|---|
| CAS Number | 2231744-29-7 | Molecular Weight | 787.82 |
| Density | N/A | Boiling Point | N/A |
| Molecular Formula | C41H41N9O8 | Melting Point | N/A |
| MSDS | N/A | Flash Point | N/A |
| Name | MT-802 |
|---|
| Description | MT-802 is a potent BTK degrader based on PROTAC technology, with a DC50 of 1 nM. MT-802 has potential to treat C481S mutant chronic lymphocytic leukemia (CLL)[1]. |
|---|---|
| Related Catalog | Research Areas >> Cancer Research Areas >> Inflammation/Immunology Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk Signaling Pathways >> PROTAC >> PROTAC |
| Target | DC50: 1 nM (BTK)[1]. |
| In Vitro | MT-802 degrades BTK with a DC50 of 9.1 nM with maximal degradation being observed by 250 nM[1]. |
| References | [1]. Buhimschi AD, et al. Targeting the C481S Ibrutinib-Resistance Mutation in Bruton's Tyrosine Kinase Using PROTAC-Mediated Degradation. Biochemistry. 2018 Jul 3;57(26):3564-3575. |
| Molecular Formula | C41H41N9O8 |
|---|---|
| Molecular Weight | 787.82 |
| Storage condition | -20°C |
Company Profile Introduction
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China- Since: 2024-04-30
- Address: Room 815, Block A, Yiyuan International Building, No.319, Xinyi Road, Zhengzhou, Henan Pilot Free Tr
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