Vitamin D3
| Price | $20 |
| Package | 1KG |
| Min. Order: | 1KG |
| Supply Ability: | Ex 20 tons |
| Update Time: | 2022-09-15 |
Product Details
| Product Name: Vitamin D3 | CAS No.: 67-97-0 |
| EC-No.: 200-673-2 | Min. Order: 1KG |
| Purity: 99% | Supply Ability: Ex 20 tons |
| Release date: 2022/09/15 |
Use of Vitamin D3
Cholecalciferol(Vitamin D3) is a naturally occuring form of vitamin D; Reported that upon metabolic activation, Cholecalciferol induces cell differentiation and prevents proliferation of cancer cells. IC50 value:Target: Vitamin D acts through a receptor that is a member of the ligand-dependent transcription factor superfamily. Modulates the proliferation and differentiation of both normal and cancer cells. Has antiproliferative and antimetastatic effects on breast, colon, and prostate cancer cells. Activated vitamin D receptors in intestine and bone maintain calcium absorbance and homeostasis.
| Description | Cholecalciferol(Vitamin D3) is a naturally occuring form of vitamin D; Reported that upon metabolic activation, Cholecalciferol induces cell differentiation and prevents proliferation of cancer cells. IC50 value:Target: Vitamin D acts through a receptor that is a member of the ligand-dependent transcription factor superfamily. Modulates the proliferation and differentiation of both normal and cancer cells. Has antiproliferative and antimetastatic effects on breast, colon, and prostate cancer cells. Activated vitamin D receptors in intestine and bone maintain calcium absorbance and homeostasis. |
|---|---|
| Related Catalog | Signaling Pathways >> Vitamin D Related >> VD/VDR Research Areas >> Cancer Natural Products >> Others |
| Target | Human Endogenous Metabolite |
| Solvent | In Vitro: DMSO : 10 mg/mL (26.00 mM; Need ultrasonic) H2O : < 0.1 mg/mL (insoluble) In Vivo: 1.Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% saline Solubility: ≥ 1 mg/mL (2.60 mM); Clear solution 2.Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in saline) Solubility: 1 mg/mL (2.60 mM); Suspended solution; Need ultrasonic 3.Add each solvent one by one: 10% DMSO 90% corn oil Solubility: ≥ 1 mg/mL (2.60 mM); Clear solution |
| Solubility | 1 mM2.5998 mL12.9992 mL25.9983 mL5 mM0.5200 mL2.5998 mL5.1997 mL10 mM0.2600 mL1.2999 mL2.5998 mL |
| Storage | 4°C, protect from light, stored under nitrogen |
| Shipping | Room temperature in continental US; may vary elsewhere |
| SMILES | C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCCC(C)C)([H])/C(CCC1)=C/C=C3C(CC[C@H](O)C\3)=C |
| References | [1]. Leibowitz SB, Kantoff PW. Differentiating agents and the treatment of prostate cancer: Vitamin D3 and peroxisome proliferator-activated receptor gamma ligands. Semin Oncol. 2003 Oct;30(5):698-708. [2]. Di Rosa M, Malaguarnera M, Nicoletti F, Malaguarnera L. Vitamin D3: a helpful immuno-modulator. Immunology. 2011 Oct;134(2):123-39. doi: 10.1111/j.1365-2567.2011.03482.x. [3]. Krishnan AV, Feldman D. Mechanisms of the anti-cancer and anti-inflammatory actions of vitamin D. Annu Rev Pharmacol Toxicol. 2011;51:311-36. doi: 10.1146/annurev-pharmtox-010510-100611. [4]. Nigwekar SU, Bhan I, Thadhani R. Ergocalciferol and cholecalciferol in CKD. Am J Kidney Dis. 2012 Jul;60(1):139-56. doi: 10.1053/j.ajkd.2011.12.035. |
| Related Molecules | 3-Methyladenine | Hydrocortisone | Acetylcysteine | Tretinoin | Melatonine | Dinoprostone | Nicotinamide | Adenosine triphosphate | 4-Acetamidophenol | Prostaglandin E1 | Dehydroepiandrosterone | Calcipotriene | Corticosterone | Progesterone | Docosahexaenoic Acid |
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