Product Details
| Product Name:
voxelotor |
CAS No.:
1446321-46-5 |
| Purity:
99.94% |
Supply Ability:
10g |
| Release date:
2024/11/15 |
Product Introduction
Bioactivity
| 名称 | voxelotor |
| 描述 | Voxelotor (GBT 440) is a novel hemoglobin S (HbS) polymerization inhibitor primarily used for the treatment of sickle cell disease (SCD) and a cytochrome P450 3A4 inhibitor. Voxelotor targets and covalently binds to the N-terminal valine of the HbS alpha chain, thereby stabilizing sickle cell hemoglobin (HbS). |
| 体内活性 | Voxelotor?treatment reduced bilirubin levels and improved jaundice[1]. |
| 存储条件 | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 125 mg/mL (370.51 mM)
|
| 关键字 | GBT440 | polymerization | haemoglobin | sickle | GBT-440 | SCD | inhibit | cell | disease | voxelotor | Inhibitor | HbS |
| 相关库 | 经典已知活性库 | EMA 上市药物库 | 药物功能重定位化合物库 | 抑制剂库 | 抗心血管疾病化合物库 | FDA 上市药物库 | 口服活性化合物库 | 已知活性化合物库 | 共价抑制剂库 | 人代谢物化合物库 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
-
CAS:188936-12-1
$67.00 / 1mg
-
CAS:52549-17-4
$42.00 / 25mg
-
CAS:864953-39-9
$52.00 / 1mg
Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$0.00/1kg |
VIP1Y
|
Shaanxi TNJONE Pharmaceutical Co., Ltd
|
2024-04-01 |
|
|
$35.00/1kg |
VIP1Y
|
Henan Fengda Chemical Co., Ltd
|
2024-03-28 |
|
|
$6.68/1KG |
VIP5Y
|
Career Henan Chemical Co
|
2020-01-08 |
United States