Product Details
| Product Name:
W146 |
CAS No.:
909725-61-7 |
| Supply Ability:
10g |
Release date:
2024/11/12 |
Product Introduction
Bioactivity
| 名称 | W146 |
| 描述 | W146 is a selective and potent Sphingosine 1-phosphate receptor subtype 1 (S1PR1) antagonist that induces significant but transient hematolymphopenia in mice.W146 induces significant but transient hematolymphopenia in mice, inducing pulmonary edema. |
| 体外活性 | W146 is an antagonist of S1PR1 (Ki: 70-80 nM). [1]
W146 pretreatment significantly increased the TUNEL labeling index of endothelial progenitor cells (EPCs) compared with the S1P-treated group. W146 pretreatment significantly increased the level of activated cleaved caspase-3. S1P was able to reduce apoptosis in EPCs, but this protective effect was completely lost after W146 treatment. [2] |
| 体内活性 | In mice, Injections of W146, W140, JTE013, or Cay10444 do not alter the basal WBC count. when mice are pretreated with W146, it is found that a significant increase in KSL-HSPC mobilization, compared to that in mice pretreated with dextran followed by AMD3100 administration. Moreover, pre-treatment of W146 shows an approximately 8-fold increase of KSL-HSPC mobilization, measured by the CFU-G/M colony-forming assays, compared to that in mice treated with AMD3100 alone. [3] |
| 存储条件 | keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 15 mg/mL(43.81 mM), Sonication is recommended.
|
| 关键字 | W146 |
| 相关产品 | Stavudine | 5-Fluorouracil | Kaempferol | Myricetin | Meclizine dihydrochloride | Rotenone | Sodium 4-phenylbutyrate | L-Ascorbic acid | Metronidazole | Sorafenib | Tributyrin | Salicylic acid |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$165.00/1mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2024-11-12 |
United States