Welcome to chemicalbook!
+1 (818) 612-2111
Inquriy
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

RFQ
skype
MY Account
Top
Postion:Product Catalog >Biochemical Engineering>Inhibitors>yk11
yk11
  • yk11
  • yk11
  • yk11
  • yk11
  • yk11

yk11 NEW

Price Get Latest Price
Package 1KG 5KG 25KG
Min. Order: 1KG
Supply Ability: 20 T each week
Update Time: 2023-08-23

Product Details

Product Name: yk11 CAS No.: 1370003-76-1
EC-No.: 1532714-185-1 Min. Order: 1KG
Purity: 98%~99% Supply Ability: 20 T each week
Release date: 2023/08/23

Article illustration

we are a supplier of chemical product raw materials. Pharmaceutical intermediates,Peptides, steroid, Testosterone products, Sarm Product, 
Caine products, Steroidhormone product . welcome to your inquiry.

 

let us give you a quote for your reference. we are confident that  we can become your regluar supplier with good service and safe shipping . door to door service. 


Contact : telegram/skype/we chat/whatsapp ID: +8613176845580  ross@zhongda-biotech.com



Article illustration


Article illustration

Article illustration


Article illustration



Article illustration

Article illustration


Article illustration





Product Name:yk11
Synonyms:YK-11-OA;(17alpha,20E)-17,20-[(1-Methoxyethylidene)bis(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid methyl ester;YK11 YK11 white powder;High quality 1370003-76-1 Sarms YK11 CAS NO.1370003-76-1 Manufacturers wholesale;YK11;YK 11;Factory supply with low price Sarms YK11 99% YK-11 in stock CAS NO.1370003-76-1;YK-11 (Mixture of diasteromers);Hot sell
CAS:1370003-76-1
MF:C25H34O6
MW:430.53
EINECS:1532714-185-1
Product Categories:1370003-76-1
Mol File:1370003-76-1.mol
Article illustration

yk11 Chemical Properties
Melting point 134-137°C
Boiling point 564.4±50.0 °C(Predicted)
density 1.22±0.1 g/cm3(Predicted)
storage temp. -20°C Freezer
solubility Chloroform (Slightly), Methanol (Slightly)
form Solid
color White to Pale Yellow
InChIKeyKCQHQCDHFVGNMK-PQUNLUOYSA-N

Safety Information
MSDS Information

yk11 Usage And Synthesis
DescriptionYK11 was first studied by Japanese researcher Yuichiro Kanno in 2011. It was found to be a partial agonist of the androgen receptor (AR), genetically selective, leading researchers to believe the compound was a SARM. YK11 is an experimental drug candidate and an unapproved substance for use in humans.
UsesYK-11 is a synthetic steroidal selective androgen receptor modulator (SARM).It is a gene-selective partial agonist of the androgen receptor (AR) and does not induce the physical interaction between the NTD/AF1 and LBD/AF2 (known as the N/C interaction), which is required for full transactivation of the AR.
Mechanism of actionYK-11 is an androgen receptor partial agonist that activates androgen receptor transcriptional activity in HEK293 cells overexpressing androgen receptors when used at a concentration of 0.1 μM.1 It induces expression of the androgen receptor target genes FKBP51 and FGF18 in HEK293 cells when used at a concentration of 10 μM. YK-11 accelerates nuclear translocation of androgen receptors without inducing interaction between the androgen receptor N- and C-termini. In C2C12 cells, YK-11 (500 nM) increases expression of the myogenic regulatory factors MyoD, Myf5, and myogenin, as well as follistatin (Fst), and induces myogenic differentiation.
References[1] Yuichiro Kanno, et al. Exp Cell Res. Differential DNA-binding and cofactor recruitment are possible determinants of the synthetic steroid YK11-dependent gene expression by androgen receptor in breast cancer MDA-MB 453 cells DOI:10.1016/j.yexcr.2022.113333
[2] Su Jin Lee, et al. Biochem Biophys Res Commun. Myostatin inhibitor YK11 as a preventative health supplement for bacterial sepsis DOI:10.1016/j.bbrc.2021.01.030
[3] Tomofumi Yatsu, et al. Biol Pharm Bull. Selective Androgen Receptor Modulator, YK11, Up-Regulates Osteoblastic Proliferation and Differentiation in MC3T3-E1 Cells DOI:10.1248/bpb.b17-00748
[4] Mario Thevis, et al. Mol Cell Endocrinol. Detection of SARMs in doping control analysis DOI:10.1016/j.mce.2017.01.040
[5] Yuichiro Kanno, et al. Biol Pharm Bull. Selective androgen receptor modulator, YK11, regulates myogenic differentiation of C2C12 myoblasts by follistatin expression DOI:10.1248/BPB.B13-00231


















































Company Profile Introduction

Shandong Huisheng Import & Export Co., Ltd. is located in Jinan city, Shandong Province, is a collection of domestic trade, international trade in one of the diversified services company. Our goal is to provide customers with high quality solutions and one-stop purchasing experience. At present, the company business scope involves five areas: Organic chemical raw materials, inorganic chemical raw materials, fine chemical raw materials, dangerous chemicals and green environmental protection chemical technology project promotion, and we has also established good relations of cooperation with several well-known enterprises and won the strong support of extensive trust from the new and old customers. Products are widely used in automobile, household appliances, office supplies, mobile phone accessories, routers, food, medical and other fields. At present, our business covers 30 countries, and our customers mainly come from Australia, New Zealand, Canada, Germany, France, Poland, South Korea, Russia, Bangladesh, Vietnam, Kazakhstan, India, Ghana, Nigeria, South Africa, Egypt and other more than 30 countries. The company has a sound quality management system and advanced professional equipment, with a positive attitude to meet the changing needs of customers. We take "quality products, quality service, competitive price, timely delivery" as the purpose, looking forward to greater cooperation with overseas customers on the basis of mutual benefit. Our company provides a wide range of products to meet your various needs. Since its inception, the company has always adhered to the "quality first, customer first, reputation first" business policy, wholeheartedly meet the potential needs of our customers. Under the irresistible situation of economic globalization, our company is willing to cooperate sincerely with enterprises around the world to achieve a win-win situation.

You may like

Recommended supplier

Product name Price   Suppliers Update time
$45.00/1Box
VIP1Y
zhuzhou dingcheng meihei comestic co.,ltd
2024-05-29
$0.00/25kg
VIP1Y
Hebei Mojin Biotechnology Co.,Ltd
2024-05-16
$20.00/1kg
VIP1Y
Shaanxi Franta Biotechnology Co., Ltd
2024-03-27
$1.00/1g
VIP4Y
Dorne Chemical Technology co. LTD
2024-03-26
$90.00/1kg
VIP1Y
hebei hongtan Biotechnology Co., Ltd
2024-03-21
$0.00/25KG
VIP5Y
Hebei Mojin Biotechnology Co., Ltd
2024-03-20
$10.00/1kg
VIP1Y
Wuhan Xinhao Biotechnology Co., Ltd
2024-02-23
$0.00/1kg
VIP1Y
Shandong Hanjiang Chemical Co., Ltd
2024-01-22
$30.00/1KG
VIP1Y
Wuhan Ruichi Technology Co., Ltd
2024-01-04
$10.00/1mg
VIP1Y
Nantong Guangyuan Chemicl Co,Ltd
2023-11-14
  • Since: 2020-11-16
  • Address: Room 202-9, Building 1, Evergrande Huafu, Dongying Road, Huaiyin District, Jinan City, Shandong Prov
INQUIRY

18963783019
da@zhongda-biotech.com