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Ramipril(87333-19-5)

Ramipril(87333-19-5)
Product IdentificationBack to Contents
【Product Name】

Ramipril
【Synonyms】

(1S,5S,7S)-8-[(2S)-2-[[(1S)-1-Ethoxycarbonyl-3-phenyl-propyl]amino]propanoyl]-8-azabicyclo[3.3.0]octane-7-carboxylic acid
Cyclopenta(b)pyrrole-2-carboxylic acid, octahydro-1-(2-((1-(ethoxycarbonyl)-3-phenylpropyl) amino)-1-oxopropyl), (2S-(1(R*(R*)),2-alpha,3a-beta,6a-beta))
HOE-498
Ramipril
【CAS】

87333-19-5
【Formula】

C23H32N2O5
【Molecular Weight】

416.52
【RTECS】

GY5879600
【Merck】

12,8283
Physical and Chemical PropertiesBack to Contents
【Solubility in water】

Insoluble
【Melting Point】

109
【Vapor Pressure】

4.9E-16 (25 C)
【Density】

1.20 g/cm3 (20 C)
【pKa/pKb】

3.17 (pKa)
【Partition Coefficient】

3.41
【Usage】

Long-acting angiotensin-converting enzyme inhibitor. It is a prodrug that is transformed in the liver to its active metabolite ramiprilat.
Handling and StorageBack to Contents
【Storage】

Store in original container in a cool dark place.
Hazards IdentificationBack to Contents
【Inhalation】

Remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen. Seek medical attention.
【Skin】

Immediately wash skin with soap and copious amounts of water for at least 15 minutes. If irritation persists, seek medical attention.
【Eyes】

Immediately flush eyes with copious amounts of water for at least 15 minutes. Seek medical advice.
【Ingestion】

If swallowed, wash out mouth with water, provided person is conscious. Seek medical advice.
Exposure Controls/Personal ProtectionBack to Contents
【Personal Protection】

Wear self-contained breathing apparatus, rubber boots & heavy rubber gloves.
Fire Fighting MeasuresBack to Contents
【Fire Fighting】

Extinguish with carbon dioxide, dry chemical powder or appropriate foam. Water spray. Wear self-contained breathing apparatus and protective clothing to prevent contact with the skin and eyes.
Accidental Release MeasuresBack to Contents
【Small spills/leaks】

Sweep-up/absorb in suitable material, place in a container and hold for disposal. Avoid raising dust. Ventilate area and wash spill site after pickup is complete.
Stability and ReactivityBack to Contents
【Combustion Products】

Emits toxic fumes under fire conditions.
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