ChemicalBook >>Rapamycin>>Sirolimus(53123-88-9)

Sirolimus(53123-88-9)

Sirolimus(53123-88-9)
Product IdentificationBack to Contents
【Product Name】

Sirolimus
【Synonyms】

(-)-Rapamycin
Antibiotic AY-22989
AY-22989
NSC-226080
SILA-9268A
Sirolimus
【CAS】

53123-88-9
【Formula】

C51H79NO13
【Molecular Weight】

914.19
【RTECS】

VE6250000
【Merck】

12,8288
【Beilstein/Gmelin】

5848501
【Beilstein Reference】

6-27
Physical and Chemical PropertiesBack to Contents
【Appearance】

White to off-white powder.
【Solubility in water】

Insoluble
【Melting Point】

183 - 184
【Density】

1.18 g/cm3
【pKa/pKb】

10.40 (pKa)
【Partition Coefficient】

3.58
【Usage】

Tool for immunochemistry.
Handling and StorageBack to Contents
【Storage】

Store solid and solutions at -20 ºC
Hazards IdentificationBack to Contents
【Inhalation】

If inhaled, remove to fresh air; if breathing is difficult, give oxygen; if breathing stops, give artificial respiration
【Skin】

Flush with copious amounts of water; remove contaminated clothing and shoes; call a physician
【Eyes】

Check for and remove contact lenses and flush with copious amounts of water; assure adequate flushing by separating the eyelids with fingers; call a physician
【Ingestion】

Wash out mouth with copious amounts of water; call a physician
Exposure Controls/Personal ProtectionBack to Contents
【Personal Protection】

Protective clothing, heavy rubber gloves, chemical safety goggles.
【Respirators】

NIOSH/MSHA-approved respirator.
【Exposure Effects】

Potent immunosuppresent; may cause irritation to eyes, skin, mucous membranes.
Fire Fighting MeasuresBack to Contents
【Fire Fighting】

Suitable extinguishing agents: water spray, carbon dioxide, dry chemical powder or foam. Protective equipment: wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Accidental Release MeasuresBack to Contents
【Small spills/leaks】

Absorb solutions with finely-powdered liquid-binding material (diatomite, universal binders); decontaminate surfaces and equipment by scrubbing with alcohol.
Stability and ReactivityBack to Contents
【Stability】

Stable if stored as directed.
【Incompatibilities】

Strong oxidizing agents.
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