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Carbamazepine(298-46-4)

Carbamazepine(298-46-4)
Product IdentificationBack to Contents
【Product Name】

Carbamazepine
【Synonyms】

5-Carbamoyl-5H-dibenz(b,f)azepine
5-Carbamoyldibenzo(b,f)azepine
5H-Dibenz(b,f)azepine-5-carboxamide
Carbazepine
Dibenz(b,f)azepine-5-carboxamide
Telesmin
【CAS】

298-46-4
【Formula】

C15H12N2O
【Molecular Weight】

236.27
【EINECS】

206-062-7
【RTECS】

HN8225000
【RTECS Class】

Drug; Mutagen; Reproductive Effector; Human Data
【Merck】

12,1826
【Beilstein/Gmelin】

1246090
【Beilstein Reference】

5-20-08-00247
Physical and Chemical PropertiesBack to Contents
【Appearance】

Crystals from absorption in ethanol + benzene.
【Solubility in water】

Insoluble
【Melting Point】

190 - 192
【Boiling Point】

411
【Vapor Pressure】

6E-7 (25 C)
【Density】

1.296 g/cm3 (-115 C)
【pKa/pKb】

13.94 (pKa)
【Partition Coefficient】

2.67
【Heat Of Vaporization】

66.3 kJ/mol
【Usage】

Medication.
First Aid MeasuresBack to Contents
【Ingestion】

Get medical aid. Wash mouth out with water.
【Inhalation】

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
【Skin】

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.
【Eyes】

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Handling and StorageBack to Contents
【Storage】

Store in a cool, dry place. Store in a tightly closed container.
【Handling】

Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Hazards IdentificationBack to Contents
【Inhalation】

May cause respiratory tract irritation.
【Skin】

May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material.
【Eyes】

May cause eye irritation.
【Ingestion】

Harmful if swallowed. May cause irritation of the digestive tract.
Exposure Controls/Personal ProtectionBack to Contents
【Personal Protection】

Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.
【Respirators】

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.
【Exposure Effects】

Ataxia, slurred speech, nystagmus, dystonias, and varying degrees of CNS depression are common. Myoclonic activity, seizures and abnormal tendon reflexes have been reported. Cyclic coma, possibly due to delayed absorption, has been reported.
Fire Fighting MeasuresBack to Contents
【Flash Point】

202
【Fire Fighting】

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.
Accidental Release MeasuresBack to Contents
【Small spills/leaks】

Vacuum or sweep up material and place into a suitable disposal container.
Stability and ReactivityBack to Contents
【Stability】

Stable under normal temperatures and pressures.
【Incompatibilities】

Strong oxidizing agents.
【Decomposition】

Nitrogen oxides, carbon monoxide, carbon dioxide.
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