Leflunomide(75706-12-6)

Contents

Product Identification	Back to Contents
【Product Name】 Leflunomide
【Synonyms】 4-Isoxazolecarboxamide, 5-methyl-N-(4-(trifluoromethyl)phenyl)- 5-Methylisoxazole-4-carboxylic acid (4-trifluoromethyl)anilide 5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamide Arava HWA-486
【CAS】 75706-12-6
【Formula】 C12H9F3N2O2
【Molecular Weight】 270.20999999999998
【RTECS】 NY2354200
【Merck】 12,10407

Physical and Chemical Properties	Back to Contents
【Solubility in water】 Insoluble
【Boiling Point】 289
【Vapor Pressure】 0.0022 (25 C)
【Density】 1.392 g/cm3 (20 C)
【pKa/pKb】 11.45 (pKa)
【Partition Coefficient】 1.95
【Heat Of Vaporization】 52.9 kJ/mol
【Usage】 Used in active moderate to severe rheumatoid arthritis and psoriatic arthritis.

Handling and Storage	Back to Contents
【Storage】 Store in original container in a cool dark place.

Hazards Identification	Back to Contents
【Inhalation】 Remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen. Seek medical attention.
【Skin】 Immediately wash skin with soap and copious amounts of water for at least 15 minutes. If irritation persists, seek medical attention.
【Eyes】 Immediately flush eyes with copious amounts of water for at least 15 minutes. Seek medical advice.
【Ingestion】 If swallowed, wash out mouth with water, provided person is conscious. Seek medical advice.

Exposure Controls/Personal Protection	Back to Contents
【Personal Protection】 Wear self-contained breathing apparatus, rubber boots & heavy rubber gloves.

Fire Fighting Measures	Back to Contents
【Flash Point】 129
【Fire Fighting】 Extinguish with carbon dioxide, dry chemical powder or appropriate foam. Water spray. Wear self-contained breathing apparatus and protective clothing to prevent contact with the skin and eyes.

Accidental Release Measures	Back to Contents
【Small spills/leaks】 Sweep-up/absorb in suitable material, place in a container and hold for disposal. Avoid raising dust. Ventilate area and wash spill site after pickup is complete.

Stability and Reactivity	Back to Contents
【Combustion Products】 Emits toxic fumes under fire conditions.

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Company Name:	Beijing HwrkChemical Technology Co., Ltd
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