ChemicalBook >>Cladribine>>2-Chloro-2'-deoxyadenosine(4291-63-8)

2-Chloro-2'-deoxyadenosine(4291-63-8)

2-Chloro-2'-deoxyadenosine(4291-63-8)
Product IdentificationBack to Contents
【Product Name】

2-Chloro-2'-deoxyadenosine
【Synonyms】

2-CdA
2-Chloro-2'-deoxyadenosine
2-Chloro-6-amino-9-(2-deoxy-b-D-erythro-pentofuranosyl)purine
2-Chlorodeoxyadenosine
Cladribine
Leustatin
【CAS】

4291-63-8
【Formula】

C10H12ClN5O3
【Molecular Weight】

285.69
【RTECS】

AU7357560
【Merck】

12,2397
【Beilstein/Gmelin】

624220
Physical and Chemical PropertiesBack to Contents
【Appearance】

White solid.
【Solubility in water】

Insoluble
【Melting Point】

220
【Vapor Pressure】

4.0E-15 (25 C)
【Density】

2.03 g/cm3 (20 C)
【pKa/pKb】

12.41 (pKb)
【Partition Coefficient】

.02
【Usage】

A drug commonly used to treat hairy cell leukemia.
First Aid MeasuresBack to Contents
【Ingestion】

Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar, tie, belt or waistband.
【Inhalation】

If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.
【Skin】

In case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient. Remove contaminated clothing and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention.
【Eyes】

Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical attention.
Handling and StorageBack to Contents
【Storage】

Keep container tightly closed, in a cool, well-ventilated area. Do not store above 4 C.
Hazards IdentificationBack to Contents
【Skin】

Hazardous in case of skin contact (irritant, permeator). Skin inflammation is characterized by itching, scaling, reddening, or, occasionally, blistering.
【EC Risk Phrase】

R: 20/21/22 36/37/38 40
【EC Safety Phrase】

S: 22 24/25 26 36/37/39 45
Exposure Controls/Personal ProtectionBack to Contents
【Personal Protection】

Impervious gloves, chemical safety goggles, lab coat.
【Exposure Effects】

May be harmful if inhaled, absorbed through the skin or swallowed. May cause irritation of the respiratory tract, eyes and skin. May cause damage to the kidneys, liver, heart, GI tract, eyes, central nervous system. May cause birth defects based on animal data.
Accidental Release MeasuresBack to Contents
【Small spills/leaks】

Use appropriate tools to put the spilled solid into a waste disposal container. Finish cleaning by spreading water on the contaminated surface.
Stability and ReactivityBack to Contents
【Incompatibilities】

Oxidizing agents.
Fire Fighting MeasuresBack to Contents
【Fire Potential】

May be combustible at high temperature. Extinguish with dry chemical powder, water spray, fog or foam. Do not use water jet. Wear positive pressure SCBA and full turnout gear.
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