| Product Identification | Back to Contents | 【Product Name】
4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinone | 【Synonyms】
4-Amino-1-arabinofuranosyl-2-oxo-1,2-dihydropyrimidine
AC-1075
Alexan
Arabinocitidine
Ara-C
Cytarabin | 【CAS】
147-94-4 | 【Formula】
C9H13N3O5 | 【Molecular Weight】
243.22 | 【EINECS】
205-705-9 | 【RTECS】
HA5425000 | 【RTECS Class】
Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data; Primary Irritant | 【Merck】
12,2853 | 【Beilstein/Gmelin】
89175 | 【Beilstein Reference】
4-25-00-03669 |
| First Aid Measures | Back to Contents | 【Ingestion】
DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. | 【Inhalation】
IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used. | 【Skin】
IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment. | 【Eyes】
First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop. |
| Handling and Storage | Back to Contents | 【Storage】
Store in a tightly closed container in a cool area. | 【Handling】
Avoid all fors of unprotected contact when mixing and administering this product. |
| Hazards Identification | Back to Contents | 【Inhalation】
Adult respiratory distress syndrome has been reported. Causes irritation. Poisonous. | 【Skin】
Rash is a common adverse effect of cytarabine therapy. Poisonous on contact. | 【Eyes】
Irritation. | 【Ingestion】
Poisonous. |
| Exposure Controls/Personal Protection | Back to Contents | 【Personal Protection】
Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots. | 【Respirators】
Wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. | 【Exposure Effects】
with therapeutic use - CNS toxicity is associated with high dose cytarabine therapy, and includes cerebral and cerebellar dysfunction. Peripheral neuropathy may develop. Teratogenicity has been reported in animal studies. |
| Fire Fighting Measures | Back to Contents | 【Fire Fighting】
Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire. |
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