英文名称：
VX-770
CAS号：
873054-44-5
分子式：
C24H28N2O3
分子量：
392.49
EINECS号：
沸点
550.4±50.0 °C(Predicted)
密度
1.187
酸度系数(pKa)
11.08±0.23(Predicted)
海关编码
29333990
Ivacaftor (10 μM) significantly increases the forskolin-stimulated Cl- secretion (IT) by ~4-fold with an EC50 of 100 nM in the recombinant Fisher rat thyroid (FRT) cells expressing G551D gating mutation of CFTR, and by ~6-fold with an EC50 of 25 nM in the recombinant cells expressing temperature-corrected F508del processing mutation of CFTR. Consistent with the increases in the forskolin-stimulated IT, Ivacaftor
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