用途21-羟基-17-(1-氧代丙氧基)孕甾-4-烯-3,20-二酮用作有机合成、医药中间体。生物活性Clascoterone(Winlevi,Cortexolone17alpha-propionate,Cortexolone17α-propionate,CB-03-01)是一种局部的和外周选择性的androgenreceptor(AR)的拮抗剂。靶点TargetValueAR()体内研究Clascoteroneisanewpotenttopicalantiandrogenpotentiallyusefulinacnevulgaris.Clascoterone1%creamwasverywelltolerated,andwassignificantlybetterthanplaceboregardingTLC(P=0·0017),ILC(P=0·0134)andASI(P=0·0090),andalsoclinicallymoreeffectivethancomparator.Theproductalsoinducedafasterattainmentof50%improvementinalltheaboveparameters.用途信号转导通路激酶抑制剂
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