中文名称：脱羧肌肽
同义词：CARCININE 二盐酸盐
产品编号：PR0146006
CAS号：57022-38-5
分子式：C8H16Cl2N4O
重量：255.144839286804
介绍：
众所周知，肌肽是一种天然存在的二肽，具有极好的清除自由基和抗糖基化作用。
Decarboxy Carnosine HCL是由肌肽脱羧而得，不仅延续了肌肽清除自由基和抵抗糖基化的能力，而且改善了自身的性质，在特定的生理环境下比肌肽更稳定。
英文名称：Carcinine dihydrochloride
CAS号：57022-38-5
分子重量：255.14
MF：C8H14N4O·2HCl
生物活性
Carcinine（β-丙氨酰组胺）是一种选择性组胺 H3 拮抗剂，对 H3 的选择性是 H2 和 H1 的 100-1000 倍，它还具有抗氧化剂和化学伴侣的作用，可减少蛋白质的非酶糖化并维持天然折叠的蛋白质。
机制
1.清除自由基，抗氧化
脱羧肌肽具有捕获羟基自由基、单质氧自由基和过氧化氢自由基的作用，能抑制非金属离子引起的脂质氧化，稳定保护细胞膜。
2. 抗糖化
皮肤发生糖基化，使胶原蛋白逐渐失去弹性，在皮肤表面形成皱纹，肤色变黄。
脱羧肌肽通过两个不同的靶点抑制结构蛋白的糖基化，保护胶原蛋白和弹性蛋白。
功能：
1.清除自由基，抗氧化。
2. 抗糖基化。
3.提亮肤色，去除黄皮。
4. 抗紫外线和污染物。
5、防止皮肤过早老化，保持皮肤年轻状态。
应用：
可添加到美容护肤品中，如乳液、面膜、早晚霜、眼霜、眼部精华、面部精华、肌底液、爽肤水、眼膜、凝胶等。
建议用量：
0.1% 在乳液和凝胶中。
安全：
体内外试验均表明脱羧肌肽不会引起任何细胞毒性、皮肤刺激、过敏和眼睛刺激。
包装：
1公斤/袋、10公斤/桶或25公斤/桶。
贮存：
密封、阴凉、清洁处保存，避强光。
保质期：24 个月。
English name: Carcinine dihydrochloride
Synonym: Decarboxy Carnosine HCL
Product ID: PR0146006
CAS NO.: 57022-38-5
Formula: C8H16Cl2N4O
Weight: 255.144839286804
Introduction:
As we all know, Carnosine is a naturally occurring dipeptide with excellent free radical scavenging and anti-glycosylation affection.
Decarboxy Carnosine HCL is derived from carnosine by decarboxylation, which not only continues carnosine's ability to scavenge free radicals and resist glycosylation, but also improves its own properties and is more stable than carnosine in a specific physiological environment.
English Name: Carcinine dihydrochloride
CAS No: 57022-38-5
MW: 255.14
MF: C8H14N4O·2HCl
Biological activity
Carcinine (β-alanyl histamine) is a selective histamine H3 antagonist, 100-1000-fold selective for H3 over H2 and H1, that also functions as an antioxidant and as a chemical chaperone to reduce non-enzymatic glycation of proteins and maintain native folding of proteins.
Mechanism
1. Scavenging free radicals, anti-oxidation
Decarboxylated carnosine has the effect of capturing hydroxyl radicals, elemental oxygen and hydrogen peroxide radicals, it can inhibit lipid oxidation caused by non-metallic ions and stably protect cell membranes.
2. Anti-glycation
Glycosylation takes place on the skin, causing collagen to gradually lose its elasticity, forming wrinkles on the skin surface, and yellowing complexion.
Decarboxylated carnosine inhibits of structural proteins glycosylation through two different targets, protecting collagen and elastin.
Function:
1. Scavenging free radicals and anti-oxidation.
2. Anti-glycosylation.
3. Brightening skin tone, removing yellow skin.
4. UV and pollutants resistance.
5. Prevent premature skin aging and maintain skin youthful state.
Application:
It Can be added to beauty skin care products, such as lotion, mask, morning and evening cream, eye cream, eye essence, facial essence, muscle foundation, toner, eye mask, gel etc.
Suggestion Dosage:
0.1% in the lotion and gel.
Security:
Both in vivo and in vitro tests showed that decarboxylated carnosine did not cause any cytotoxicity, skin irritation, allergy and eye irritation.
Packing:
1kg/Bag, 10kg/Drum or 25kgs/Drum.
Storage:
Keep in Sealed, Cool, clean place, and Avoid strong Light.
Shelf Life: 24 months.
关键字： Decarboxylation ;脱羧肌肽;Propanamide;Decarboxylation ;dihydrochloride;
迪克曼致力于功能性化合物研发，包括生物抑制剂、荧光探针与染料、抗体佐剂、保健食品和化妆品原料、药物中间体等，并提供定制合成、合同研究及大包装服务。