1,3-Dihydroxyacetone Basic informationProduct Name:1,3-DihydroxyacetoneSynonyms:PROPANE-1,3-DIOL-2-ONE;1,3-dihydroxy-2-propanon;1,3-Dihydroxydimethyl ketone;1,3-Dihydroxypropanone;Aliphatic ketone;Chromelin;Dihyxal;KetochrominCAS:96-26-4MF:C3H6O3MW:90.08EINECS:202-494-5Product Categories:Pharmaceutical intermediates;Imidazoles;VX:15689727968Mol File:96-26-4.mol 1,3-Dihydroxyacetone Chemical PropertiesMelting point 75-80 °CBoiling point 107.25°C (rough estimate)density 1.1385 (rough estimate)FEMA 4033 | DIHYDROXYACETONErefractive index 1.4540 (estimate)storage temp. Store at +2°C to +8°C.pka12.45±0.10(Predicted)form powdercolor WhiteWater Solubility >250 g/L (20 ºC)JECFA Number1716Stability:Stable. Combustible. Hygroscopic.CAS DataBase Reference96-26-4(CAS DataBase Reference)NIST Chemistry Reference2-Propanone, 1,3-dihydroxy-(96-26-4)EPA Substance Registry System2-Propanone, 1,3-dihydroxy- (96-26-4) Safety InformationSafety Statements 24/25HS Code 29141900Hazardous Substances Data96-26-4(Hazardous Substances Data)ToxicityCHROMELIN ? DIHYDROXYACETONE ? 1,3DIHYDROXYACETONE ? 1,3-DIHYDROXYPROPANONE ? DIHYXAL ? NSC-24343 ? OTAN ? OXATONE ? SOLEAL ? 2PROPANONE, 1,3-DIHYDROXY- ? TRIULOSE ? VITICOLOR 1,3-Dihydroxyacetone Usage And SynthesisChemical Propertieswhite powderChemical PropertiesDihydroxyacetone has a characteristic sweet, cooling aroma.OccurrenceA derivative of naturally occurring starchUses1,3-Dihydroxyacetone can be used as artificial tanning agent.Uses1,3-Dihydroxyacetone (DHA) is a self-tanning agent used in cosmetics designed to provide a tanned appearance without the need for sun exposure. It is also a uV protector and a color additive. As a self-tanning agent, it reacts with amino acids found on the skin’s epidermal layer. Its effects last only a few days as the color it provides fades with the natural shedding of the stained cells. Reportedly, it works best on slightly acidic skin. DHA, when combined with lawsone, becomes an FDA Category I (approved) uV protectant. In 1973, the FDA declared that DHA is safe and suitable for use in cosmetics or drugs that are applied to color the skin, and has exempted it from color additive certification.DefinitionChEBI: A ketotriose consisting of acetone bearing hydroxy substituents at positions 1 and 3. The simplest member of the class of ketoses and the parent of the class of glycerones.PreparationUsually produced commercially from Bacillus macerans or Bacillus circulans fermentation of starch or starch hydrolysateTaste threshold valuesReported to have a taste threshold value lower than that of sucrose with a detection level of 3.9 to 27 ppm and a recognition level of 11 to 52 ppm.Safety ProfileMutation data reported. When heated to decompositionit emits acrid smoke and irritating vapors. 1,3-Dihydroxyacetone Preparation Products And Raw materialsRaw materials1,3-DIBROMOACETONE-->1,3-DIIODOACETONE-->1,3-Dioxan-5-one,2-phenyl-(9CI)-->1,3-DichloroacetonePreparation Products4-Imidazolemethanol hydrochloride-->DL-GLYCERALDEHYDE-->6-BROMOMETHYL-PTERIDINE-2,4-DIAMINE HBR-->NA-->(2,4-DIAMINOPTERIDIN-6-YL)METHANOL HYDROCHLORIDE HYDRATE-->glyceric acid-->Glycolic acid-->Formic acid-->2-Pentanone, 1,3,4,5-tetrahydroxy-4-(hydroxymethyl)--->MANNOSE-->4-METHYLFORMANILIDE-->PROPYL FORMATE-->DL-ARABINOSE-->D-(-)-THREOSE-->D-Glyceraldehyde |
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