Target: Autophagy:EGFR
Pathway: Autophagy:JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Biological Activity:Afatinib (BIBW 2992) is an irreversible EGFR family inhibitor with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively.
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