中文名称
S18886
英文名字
供应商
开曼生物
产品货号
14059-10
产品报价
¥1447.6/10mg
产品说明书
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购买方式
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产品新闻
背景资料
The lipid mediator thromboxane A2 (TXA2) plays a key role in platelet aggregation and vascular and bronchial smooth muscle constriction. The actions of TXA2 are mediated by its specific G protein coupled-receptor, referred to as the TXA2 receptor or TP. S18886 is an orally active, long-acting antagonist of the TP receptor with an IC50 value of 16.4 nM.{Wang} It inhibits TP receptor-mediated vascular contractions, platelet aggregation, and adhesion and infiltration of monocytes/macrophages in various pre-clinical and clinical models of thrombosis or atherosclerosis.{26175,30019,30020,30018} S18886 is the active isomer of the potent TP receptor antagonist, S18204.{30022} Antagonists of TP receptors have advantages over aspirin (Item No. 70260) as they not only block the effect of TXA2 on platelets, but also inhibit other ligands such as prostaglandin endoperoxides and isoprostanes.{30018,26175}
产品描述
An orally active, long-acting antagonist of the TP receptor (IC50 = 16.4 nM); inhibits TP receptor-mediated vascular contractions, platelet aggregation, and adhesion and infiltration of monocytes/macrophages in various pre-clinical and clinical models of thrombosis or atherosclerosis
保存建议
建议您在收到开曼生物品牌的S18886 (10 mg)产品后置于-20℃保存.
其他
开曼生物向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒,其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.开曼生物可提供用于检测的特色试剂盒,如:类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等;也提供多种高质量试剂,包括:类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为开曼生物在中国的区域总代理,艾美捷科技有限公司将为中国客户提供最全面的开曼生物产品以及客户订制化服务.
武汉艾美捷科技有限公司
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