MM-401(MM 401;MM401)

MM-401 (MM 401;MM401) is a potent inhibitor of MLL1/WDR5 protein-protein interaction with IC50 of 0.9 nM; represents over 3 and 700 folds more potency relative to MM-101 (IC50=2.9 nM) and the WDR5-interacting motif in MLL1 (WIN, IC50=750 nM); specifically blocks proliferation of MLL cells and induces changes in gene expression similar to those of MLL1 deletion; reprograms mouse epiblast stem cells (EpiSCs) to naive pluripotency.