Esomeprazole Mg pellets has been produced by Fluid-bed by spraying drug suspension onto blank sugar pellets. The drug-loaded pellets were subsequently coated with Eudragit aqueous dispersion to achieve sustained-release (SR) characteristics. Furthermore, the SR pellets were coated with Eudragit aqueous dispersion to achieve enteric properties. Besides, isolated coating film was necessary between drug layer and SR layer, as well as SR and enteric-coated layer to protect from their possible reaction. The resulting pellets were filled into the hard gelatin capsules for in vitro release processing and single-dose pharmacokinetic study in rats.
江苏中邦制药有限公司
联系商家时请提及chemicalbook,有助于交易顺利完成!