Name: LDN-05233
CAS#: 1387005-23-3
Chemical Formula: C36H52N8O9
Exact Mass: 740.3857
Molecular Weight: 740.859
Elemental Analysis: C, 58.36; H, 7.08; N, 15.13; O, 19.44
Description: LDN-05233 is a fluorogenic substrate for sirtuin 1 (SIRT1), SIRT2, and SIRT3. It is selectively deacylated by SIRT1-3 over SIRT6. Upon enzymatic cleavage by SIRT1, SIRT2, or SIRT3, LDN-05233 is released and its fluorescence can be used to quantify SIRT1, SIRT2, and SIRT3 activity. LDN-05233 displays excitation/emission maxima of 340-360/440-460 nm, respectively.
IUPAC/Chemical Name: (S)-N-((S)-1-(((S)-6-acetamido-1-((4-methyl-2-oxo-2H-chromen-7-yl)amino)-1-oxohexan-2-yl)amino)-6-amino-1-oxohexan-2-yl)-1-(acetyl-L-glutaminyl)pyrrolidine-2-carboxamide
InChi Key: LHVYYJGFOAKRPP-DZUOILHNSA-N
InChi Code: InChI=1S/C36H52N8O9/c1-21-19-32(48)53-30-20-24(12-13-25(21)30)41-33(49)26(10-5-7-17-39-22(2)45)42-34(50)27(9-4-6-16-37)43-35(51)29-11-8-18-44(29)36(52)28(40-23(3)46)14-15-31(38)47/h12-13,19-20,26-29H,4-11,14-18,37H2,1-3H3,(H2,38,47)(H,39,45)(H,40,46)(H,41,49)(H,42,50)(H,43,51)/t26-,27-,28-,29-/m0/s1
SMILES Code: NCCCC[C@H](NC([C@@H]1CCCN1C([C@@H](NC(C)=O)CCC(N)=O)=O)=O)C(N[C@@H](CCCCNC(C)=O)C(NC2=CC=C3C(C)=CC(OC3=C2)=O)=O)=O
Appearance: Solid powder
关键字： 1387005-23-3;LDN-05233;
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