Name: JKE-1674
CAS#: 2421119-60-8
Chemical Formula: C20H20Cl2N4O4
Exact Mass: 450.0862
Molecular Weight: 451.3
Elemental Analysis: C, 53.23; H, 4.47; Cl, 15.71; N, 12.41; O, 14.18
Description: JKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4) and an active metabolite of the GPX4 inhibitor ML-210. JKE-1674 reduces viability of LOX-IMVI cancer cells and in a panel of additional cancer cell lines, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1
IUPAC/Chemical Name: (E)-1-(4-(bis(4-chlorophenyl)methyl)piperazin-1-yl)-2-(hydroxyimino)-3-nitropropan-1-one
InChi Key: XIOHKIAPXVDWCP-PTGBLXJZSA-N
InChi Code: InChI=1S/C20H20Cl2N4O4/c21-16-5-1-14(2-6-16)19(15-3-7-17(22)8-4-15)24-9-11-25(12-10-24)20(27)18(23-28)13-26(29)30/h1-8,19,28H,9-13H2/b23-18+
SMILES Code: O=C(C(C[N+]([O-])=O)=NO)N1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=C(Cl)C=C3)CC1
Appearance: Solid powder
关键字： 2421119-60-8;JKE-1674;
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