Name: GNF-1331
CAS#: 603101-22-0
Chemical Formula: C20H20N6O2S2
Exact Mass: 440.1089
Molecular Weight: 440.54
Elemental Analysis: C, 54.53; H, 4.58; N, 19.08; O, 7.26; S, 14.55
Description: GNF-1331 is a Potent, Selective, and Orally Bioavailable Porcupine Inhibitor (IC50 = 12 nM). Blockade of aberrant Wnt signaling is an attractive therapeutic approach in multiple cancers. Wnt signaling is tightly controlled during cellular proliferation, differentiation, and embryonic morphogenesis. Aberrant activation of this pathway plays a critical role in a variety of cancers, such as cutaneous squamous cell carcinoma (SCC), breast cancer, and colorectal cancer.
IUPAC/Chemical Name: N-(6-methoxybenzo[d]thiazol-2-yl)-2-((4-propyl-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide
InChi Key: JIUFLMSAFMXEEC-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H20N6O2S2/c1-3-10-26-18(13-6-8-21-9-7-13)24-25-20(26)29-12-17(27)23-19-22-15-5-4-14(28-2)11-16(15)30-19/h4-9,11H,3,10,12H2,1-2H3,(H,22,23,27)
SMILES Code: O=C(NC1=NC2=CC=C(OC)C=C2S1)CSC3=NN=C(C4=CC=NC=C4)N3CCC
Appearance: Solid powder
关键字： 603101-22-0;GNF-1331;
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