Name: Moexipril-d5
CAS#: 1356929-49-1
Chemical Formula: C27H29D5N2O7
Exact Mass: 503.268
Molecular Weight: 503.6065
Elemental Analysis: C, 64.39; H, 7.80; N, 5.56; O, 22.24
Description: Moexipril-d5 intended for use as an internal standard for the quantification of moexipril by GC- or LC-MS. Moexipril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor moexiprilat. It is converted to moexiprilat in vivo by side chain ester hydrolysis. Moexipril inhibits ACE in a cell-free assay (IC50 = 2.7 µM for the rabbit enzyme). It also inhibits phosphodiesterase 4 (IC50s = 38, 160, and 230 µM for PDE4B2, PDE4A5 and PDE4D5, respectively). Moexipril (0.1-30 mg/kg per day) reduces blood pressure in spontaneously hypertensive rats.1 It also reduces infarct volume in a rat model of focal cerebral ischemia when used at a concentration of 0.01 mg/kg.
IUPAC/Chemical Name: (S)-2-(((S)-1-ethoxy-1-oxo-4-(phenyl-d5)butan-2-yl)-L-alanyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
InChi Key: UWWDHYUMIORJTA-SBCWFVTISA-N
InChi Code: InChI=1S/C27H34N2O7/c1-5-36-27(33)21(12-11-18-9-7-6-8-10-18)28-17(2)25(30)29-16-20-15-24(35-4)23(34-3)14-19(20)13-22(29)26(31)32/h6-10,14-15,17,21-22,28H,5,11-13,16H2,1-4H3,(H,31,32)/t17-,21-,22-/m0/s1/i6D,7D,8D,9D,10D
SMILES Code: [2H]C1=C(C([2H])=C(C([2H])=C1CC[C@H](N[C@H](C(N2CC3=CC(OC)=C(C=C3C[C@H]2C(O)=O)OC)=O)C)C(OCC)=O)[2H])[2H]
Appearance: Solid powder
关键字： 1356929-49-1;Moexipril-d5;
北京百奥创新科技有限公司是一家专注于生命科学的科技企业，由在国内科研试剂领域有着丰富从业经验的技术团队和管理团队组建而成，专营进口生物试剂，科学仪器，实验消耗品等。公司与诸多国外品牌签下代理，RD、Abcam、CST、Genetex、Biolegend、ebioscience、polypure、polyplus、Bethyl、Novus等，能为广大科研用户提供数万种试剂、仪器和实验消耗品。
公司将不断把上优质的产品引入国内市场，满足客户的需求，公司也将紧跟生命科学的发展，为广大科研工作者探索生命科学的奥秘奉献绵薄之力！