Name: CMP3a
CAS#: 2225902-88-3
Chemical Formula: C28H27F3N6O2S
Exact Mass: 568.1868
Molecular Weight: 568.6192
Elemental Analysis: C, 59.14; H, 4.79; F, 10.02; N, 14.78; O, 5.63; S, 5.64
Description: CMP3a is a NEK2 kinase inhibitor. CMP3a efficiently attenuated GBM growth in a mouse model and exhibited a synergistic effect with radiotherapy. Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2.
IUPAC/Chemical Name: (R)-5-{7-[1-(2-Dimethylamino-ethyl)-1H-pyrazol-4-yl]-imidazo[1,2-a]pyridin-3-yl}-3-[1-(2-trifluoromethyl-phenyl)-ethoxy]-thiophene-2-carboxamide
InChi Key: BQODGOMHYSMCGK-QGZVFWFLSA-N
InChi Code: InChI=1S/C28H27F3N6O2S/c1-17(20-6-4-5-7-21(20)28(29,30)31)39-23-13-24(40-26(23)27(32)38)22-15-33-25-12-18(8-9-37(22)25)19-14-34-36(16-19)11-10-35(2)3/h4-9,12-17H,10-11H2,1-3H3,(H2,32,38)/t17-/m1/s1
SMILES Code: O=C(C1=C(O[C@@H](C2=CC=CC=C2C(F)(F)F)C)C=C(C3=CN=C4C=C(C5=CN(CCN(C)C)N=C5)C=CN43)S1)N
Appearance: Yellow solid powder
关键字： 2225902-88-3;CMP3a;
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