Name: STX140
CAS#: 401600-86-0
Chemical Formula: C19H28N2O7S2
Exact Mass: 460.1338
Molecular Weight: 460.56
Elemental Analysis: C, 49.55; H, 6.13; N, 6.08; O, 24.32; S, 13.92
Description: STX140 is a bis-sulfamate derivative of the endogenous steroid 2-methoxyestradiol, has shown promising anticancer potency both in vitro and in vivo, with excellent bioavailability. STX140 is efficacious in vitro and in vivo in taxane-resistant breast carcinoma cells. STX140 causes apoptosis via the intrinsic mitochondrial pathway and down-regulate survivin and XIAP expression in ovarian and prostate cancer cells.
IUPAC/Chemical Name: (8R,9S,13S,14S,17S)-2-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diyl bis(sulfamate)
InChi Key: AQSNIXKAKUZPSI-SSTWWWIQSA-N
InChi Code: InChI=1S/C19H28N2O7S2/c1-19-8-7-12-13(15(19)5-6-18(19)28-30(21,24)25)4-3-11-9-17(27-29(20,22)23)16(26-2)10-14(11)12/h9-10,12-13,15,18H,3-8H2,1-2H3,(H2,20,22,23)(H2,21,24,25)/t12-,13+,15-,18-,19-/m0/s1
SMILES Code: C[C@@]12[C@@H](OS(=O)(N)=O)CC[C@@]1([H])[C@]3([H])CCC4=C(C=C(OC)C(OS(=O)(N)=O)=C4)[C@@]3([H])CC2
Appearance: Solid powder
关键字： 401600-86-0;STX140;
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