Name: Oxanosine
CAS#: 80394-72-5
Chemical Formula: C10H12N4O6
Exact Mass: 284.0757
Molecular Weight: 284.228
Elemental Analysis: C, 42.26; H, 4.26; N, 19.71; O, 33.77
Description: Oxanosine is an analog of guanosine that has been found in S. capreolus and has diverse biological activities, including antibacterial, antiviral, and anticancer properties. It is active against a variety of bacteria, including S. flexneri, P. mirabilis, and E. coli (MICs = 6.25, 12.5, 25 µg/ml, respectively, on peptone, but not nutrient, agar). Oxanosine inhibits replication of the HIV-1 strain IIIb in infected CEM and U937, but not H9, cells (EC50s = 7, 27, and >500 µg/ml, respectively). It also inhibits the growth of HeLa human cervical cancer cells (IC50 = 32 µg/ml) and reduces tumor growth in a murine L1210 lymphocytic leukemia model.
IUPAC/Chemical Name: 5-amino-3-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)imidazo[4,5-d][1,3]oxazin-7(3H)-one
InChi Key: PWVUOVPUCZNICU-ZIYNGMLESA-N
InChi Code: InChI=1S/C10H12N4O6/c11-10-13-7-4(9(18)20-10)12-2-14(7)8-6(17)5(16)3(1-15)19-8/h2-3,5-6,8,15-17H,1H2,(H2,11,13)/t3-,5-,6-,8-/m1/s1
SMILES Code: OC[C@H]1O[C@@]([H])(N2C=NC3=C2N=C(OC3=O)N)[C@H](O)[C@@H]1O
Appearance: Solid powder
关键字： 80394-72-5;Oxanosine;
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