Name: Oxocarbazate
CAS#: 1014405-03-8
Chemical Formula: C28H33N5O6
Exact Mass: 535.2431
Molecular Weight: 535.6
Elemental Analysis: C, 62.79; H, 6.21; N, 13.08; O, 17.92
Description: Oxocarbazate, also known as CID23631927, is an inhibitor of human cathepsin L. In the cathepsin L inhibition assay, The oxocarbazate caused a time-dependent 17-fold drop in IC50 from 6.9 nM (no preincubation) to 0.4 nM (4-h preincubation). Slowly reversible inhibition was demonstrated in a dilution assay. CID23631927 demonstrate activity in blocking both SARS-CoV (IC50 = 273 nM) and Ebola virus (IC50 = 193 nM) entry into human embryonic. CID 23631927 was a subnanomolar, slow-binding, reversible inhibitor of human cathepsin L that blocked SARS-CoV and Ebola pseudotype virus entry in human cells. Inhibition of cathepsin L thus holds promise for therapeutic intervention for both SARS-CoV and Ebola virus infection.
IUPAC/Chemical Name: N-[(1,1-Dimethylethoxy)carbonyl]-L-tryptophan 2-[[2-(3,4-dihydro-1(2H)-quinolinyl)-2-oxoethoxy]carbonyl]hydrazide
InChi Key: MITOFRSPGLYHSJ-QFIPXVFZSA-N
InChi Code: InChI=1S/C28H33N5O6/c1-28(2,3)39-26(36)30-22(15-19-16-29-21-12-6-5-11-20(19)21)25(35)31-32-27(37)38-17-24(34)33-14-8-10-18-9-4-7-13-23(18)33/h4-7,9,11-13,16,22,29H,8,10,14-15,17H2,1-3H3,(H,30,36)(H,31,35)(H,32,37)/t22-/m0/s1
SMILES Code: O=C(NNC(OCC(N1CCCC2=C1C=CC=C2)=O)=O)[C@@H](NC(OC(C)(C)C)=O)CC3=CNC4=C3C=CC=C4
Appearance: Solid powder
关键字： 1014405-03-8;Oxocarbazate;
北京百奥创新科技有限公司是一家专注于生命科学的科技企业，由在国内科研试剂领域有着丰富从业经验的技术团队和管理团队组建而成，专营进口生物试剂，科学仪器，实验消耗品等。公司与诸多国外品牌签下代理，RD、Abcam、CST、Genetex、Biolegend、ebioscience、polypure、polyplus、Bethyl、Novus等，能为广大科研用户提供数万种试剂、仪器和实验消耗品。
公司将不断把上优质的产品引入国内市场，满足客户的需求，公司也将紧跟生命科学的发展，为广大科研工作者探索生命科学的奥秘奉献绵薄之力！