Product Name:Exendin-4 (3-39)
Synonyms:Exendin(3-39)
Cas No.:196109-31-6
Exendin-4 (3-39)是Exenatide的片段多肽,由37个氨基酸组成,保留了Exenatide的大部分结构。
Exendin-4 (3-39) is a fragmented peptide of Exenatide, which consists of 37 amino acids and retains most of the structure of Exenatide.
Catalog No.:GT-P172
Key Specification:
Appearance: White powder
Purity (HPLC) ≥98.0%
Single impurity≤1.5%
Peptide content≥70.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Package:
Vacuum-packed with aluminum foil bag or transparent bag. 10mg,50mg, 100mg,1g,10g, 50g per package with icebag. Or according to your request.
Description:
艾塞那肽(exenatide)为胰高血糖素样肽-1(GLP-1)类似物exendin-4的人工合成品,Exendin-4 (3-39)是Exenatide的片段多肽,由37个氨基酸组成,保留了Exenatide的大部分结构。其结构中的Asn残基在高pH值和高温下易发生脱酰胺反应形成Asp,His和Trp残基较易发生氧化,由Asp参与形成的肽键比其他肽键更易水解断裂,除Gly外,其他所有氨基酸残基易在碱催化下发生消旋反应,在碱性条件下Thr残基可通过β消除发生降解。因此在多肽合成过程中,需要实用合理的生产工艺。
Exenatide is a synthetic product of exendin-4, an analog of glucagon-like peptide-1 (GLP-1). Exendin-4 (3-39) is a fragment of Exenatide peptide, consisting of 37 amino acids , Retaining most of the structure of Exenatide. The Asn residues in its structure are prone to deamidation reaction to form Asp at high pH and high temperature. His and Trp residues are more prone to oxidation. The peptide bond formed by Asp is more prone to hydrolysis and cleavage than other peptide bonds, except for Gly , All other amino acid residues are prone to racemization reaction under base catalysis, and Thr residues can be degraded by β elimination under alkaline conditions. Therefore, in the process of peptide synthesis, a practical and reasonable production process is required.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(3-letter code) | H-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 |
Sequence(1-letter code) | EGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 |
Peptide Structure |
|
Molecular Formula | C176H272N46O58S |
Molecular Weight | 3992.38 |
订购方式:
杭州固拓生物科技有限公司
手机: +86-15572296305 (同微信号)
QQ: 3187976021
邮箱:sales4@gotopbio.com
地址:杭州下沙经济技术开发区银海街600号1幢5层501 (310018)
关键字: 196109-31-6;艾塞那肽片段多肽;Exendin-4 (3-39);多肽合成;多肽;
公司介绍
杭州固拓生物科技有限公司成立于2014年,是一家专业从事多肽以及相关衍生物研发和生产的国家高新技术企业,也是中国生化制药工业协会多肽分会的理事单位。公司目前在杭州建有一个多肽研发中心,占地2000多平方米,浙江上虞和安吉有两个商业多肽合作工厂,拥有数条完善的多肽生产线, 数台大型的多肽合成设备,进口HPLC分析和制备设备,并配有GMP标准的洁净实验室。公司员工40多人,其技术骨干都是从事多肽行业15年左右,能独立自主开发多肽项目。目前公司已有成熟的药物多肽产品40多个,年产多肽可达100kg以上。定制多肽已累计达20000条,可以帮客户提供从研发级(mg)-中试-产业化生产(kgs)的一站式服务。
我们的产品和服务范围包括:
1.定制研发多肽,新抗原多肽定制合成
2.多肽原料药中间体的生产
3.多肽CRO和CDMO服务
4.化妆品多肽的生产及配方开发
5.特殊保护氨基酸以及小分子化合物合成
6.商品化多肽库的建立
7.新药研究开发的技术支持