Description: Alpha-Lipoic Acid Choline Ester, also known as alpha-LACE, EV-06 or UNR844, is a drug candidate potentially for the treatment of presbyopia. Alpha-LACE was designed to permeate biological membranes with the incorporation of the cationic choline head group. While lipoic acid does not permeate the cornea, the choline ester derivative of lipoic acid permeates the cornea, is hydrolyzed by corneal esterases and is transformed into the biologically active lipoic acid. LACE has been formulated into an ophthalmic solution to be applied twice daily as an eye-drop to treat presbyopia.
Name: Alpha-Lipoic Acid Choline Ester
CAS#: 1808266-58-1 (chloride)
Chemical Formula: C13H26ClNO2S2
Exact Mass:
Molecular Weight: 327.93
Elemental Analysis: C, 47.62; H, 7.99; Cl, 10.81; N, 4.27; O, 9.76; S, 19.55
Synonym: EV-06; EV06; EV 06; alpha-LACE; alphaLACE; alpha LACE; UNR844; UNR-844; UNR 844; Alpha-Lipoic Acid Choline Ester;
IUPAC/Chemical Name: (R)-2-((5-(1,2-dithiolan-3-yl)pentanoyl)oxy)-N,N,N-trimethylethan-1-aminium chloride
InChi Key: QMADNKDMPGZUKN-UTONKHPSSA-M
InChi Code: InChI=1S/C13H26NO2S2.ClH/c1-14(2,3)9-10-16-13(15)7-5-4-6-12-8-11-17-18-12;/h12H,4-11H2,1-3H3;1H/q+1;/p-1/t12-;/m1./s1
SMILES Code: C[N+](C)(C)CCOC(CCCC[C@H]1SSCC1)=O.[Cl-]
Appearance: Solid powder or semisolid (this product is highly hygroscopic powder)
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
关键字: 1808266-58-1;Lipoic Acid Choline ;
北京百奥创新科技有限公司是一家专注于生命科学的科技企业,由在国内科研试剂领域有着丰富从业经验的技术团队和管理团队组建而成,专营进口生物试剂,科学仪器,实验消耗品等。公司与诸多国外品牌签下代理,RD、Abcam、CST、Genetex、Biolegend、ebioscience、polypure、polyplus、Bethyl、Novus等,能为广大科研用户提供数万种试剂、仪器和实验消耗品。
公司将不断把上优质的产品引入国内市场,满足客户的需求,公司也将紧跟生命科学的发展,为广大科研工作者探索生命科学的奥秘奉献绵薄之力!