葡萄糖基鞘氨醇，植物

中文名称

葡萄糖基鞘氨醇，植物

英文名字

Glucosylsphingosine, plant

供应商

Matreya

产品货号

1310-5

背景资料

Glucosylsphingosine is the lyso-derivative of the common glycolipid glucocerebroside. Gaucher disease is characterized by an accumulation of glucocerebroside due to a deficiency in the enzyme glucocerebrosidase and it has now been found that glucopsychosine also accumulates in this disease.1 This accumulation of glucosylsphingosine contributes to neuronal dysfunction and destruction in patients with neuronopathic Gaucher disease2 and it has been found to be a potent inhibitor of glucocerebrosidase. At least some instances of Gaucher disease also have a deficiency in the activity of glucosylsphingosine beta-glucosidase, the enzyme responsible for cleaving off the glucose of glucopsychosine and glucocerebroside. Like glucocerebroside and galactocerebroside, glucosylsphingosine can increase Ca2 + mobilization from intracellular stores although it uses a different mechanism.3 Conduritol B epoxide (CBE), an inhibitor of beta-glucosidase, and l-phenyl-2- decanoylamino-3-morpholino-l-propanol (PDMP), an inhibitor of glucosylceramide synthase, can be used to create a model of Gaucher disease and consequently an accumulation of glucosylsphingosine.4

产品描述

lyso-Glucocerebroside|1-beta-D-Glucosylsphingadienine|Glucopsychosine

产品形式

该葡萄糖基鞘氨醇，植物产品为固体形式

保存建议

对于本产品，我们推荐使用-20℃蓝冰低温进行运输。在您收到货物后，我们建议在-20℃温度下冷冻保存，溶解使用说明请参考本品说明书。

其他