中文名称

组蛋白H3（瓜氨酸化R2 + R8 + R17）多抗

英文名字

Histone H3 (Citrullinated R2 + R8 + R17) Polyclonal Antibody

供应商

开曼公司

产品货号

17855-1

背景资料

Histones are nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. The basic structure is a 146bp strand of DNA wrapped around a histone octamer containing pairs of the four core histones (H2A, H2B, H3, and H4). Histones are subjected to numerous post-translational modifications including citrullination (de-imination). Citrullination is necessary for the development of neutrophil extracellular traps (NETs) (hyper-citrullination of histones by PAD4).{28015,28019} NETs are a part of the inflammatory response, and neutrophils use NETs to trap and eradicate bacteria and fungi. Failure to clear citrullinated proteins and NET components following inflammation can result in the production of autoantibodies and anti-citrullinated protein antibodies.{28017} The persistence of these antibodies and citrullinated proteins is associated with a number of human diseases including rheumatoid arthritis, systemic lupus erythematosus, Alzheimer’s disease, and multiple sclerosis.{28018} The ability to effectively detect the presence of citrullinated proteins is difficult and presents a barrier to further the understanding of these pathologies. Cayman’s Histone H3 (Citrullinated R2 + R8 + R17) Polyclonal Antibody detects citrullinated human H3 and by western blot, and does not detect unmodified H3.

应用类型

ELISA,WB

免疫原

histone 3 peptide with citrullinations at R2, R8, and R17

来源宿主

兔

反应性

人

保存建议

建议您收到开曼公司的组蛋白H3（瓜氨酸化R2 + R8 + R17）多抗产品后将其置于-20℃保存.

其他

开曼公司向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒，其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.开曼公司可提供用于检测的特色试剂盒，如：类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等；也提供多种高质量试剂，包括：类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.