中文名称
英文名字
Recombinant Human Matrix Metalloproteinase-7, Active
供应商
ProSpec
产品货号
ENZ-271
背景资料
Matrix metalloproteinase-7(MMP-7) also known as matrilysin and PUMP(EC 3.4.24.23) cleaves a number of substrates including collagen types IV and X, elastin, fibronectin, gelatin, laminin and proteoglycans. MMP-7 is closely related to the stromelysin family members but is encoded by a different gene. MMP-7 is the smallest of all the MMPs consisting of a pro-peptide domain and a catalytic domain. It lacks the hemopexin-like domain common to other members of the MMPs. MMP-7 is secreted as a 28 kDa proenzyme and can be activated in vitro by organomercurials and trypsin and in vivo by MMP-3 to a 18 kDa active MMP-7 enzyme. Once activated, MMP-7 can activate pro-MMP-1 and pro-MMP-9 but not pro-MMP-2. MMP-7 is widely expressed having been reported in elevated levels in cycling endometrium as well as in colorectal cancers and adenomas, hepatocellular carcinomas, rectal carcinomas, and approximately 50% of gliomas.
序列
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来源宿主
大肠杆菌中重组表达
溶解建议
提供的人基质金属蛋白酶-7(MMP 7)产品为灭菌的透明溶液;其中人基质金属蛋白酶-7(MMP 7)产品溶解于10mM HEPES(pH 7.4), 5mM CaCl2,150mM NaCl溶液中.
保存建议
人基质金属蛋白酶-7(MMP 7)溶液可以在4℃冷藏保存3周;如果想延长保存时间,建议分装后置于-18℃冻存.请避免反复冻融.
其他
ProSpec 是一家全球著名细胞因子蛋白生产和研发的公司,具有20多年的生产经验,专注于蛋白(重组及合成)生产研发。我们的核心产品包括:干扰素、白介素、骨蛋白、肿瘤坏死因子、成纤维生长因子、瘦素、干细胞因子、催乳素、表皮生长因子、胰岛素样生长因子、神经生长因子、集落刺激因子、激素、酶、病毒抗原以及各种重组蛋白等。 领先的生产工艺和规模使其可以提供毫克到克级蛋白,价格优于同类公司。绝大部分产品是天然成熟型蛋白,而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液,ProSpec-Tany绝大部分产品没有添加保护剂或盐,这就对工艺提出了更高的要求。同时,ProSpec-Tany绝大部分产品为冻干粉,因此易于运输和保存。
湖北艾普蒂生物工程有限公司
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