别名
4-[[[(4-Fluorophenyl)amino]carbonyl]amino]-benzenesulfonamide,NSC 213841
生化/生理作用
U-104 is an inhibitor of CA IX that binds only to CA IX under hypoxic conditions in vivo. The binding results in significant inhibition of tumor growth and metastasis formation in both spontaneous and experimental models of metastasis. U-104 reduces the medium acidity by inhibiting the catalytic activity of the CA IX. It binds specifically only to hypoxic cells expressing CA IX.
Sigma-Aldrich西格玛奥德里奇(上海)贸易有限公司
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