产品属性：
产品名称 | 规格 | CAS号 | 型号 |
24, 25-Dihydroxy VD3 | 1mg | 40013-87-4 | EY-Y0163475 |
Cas No.40013-87-4
别名 N/A
化学名 (6R)-6-[(1R,3aS,4E,7aR)-4-[(2Z)-2-[(5S)-5-hydroxy-2-methylidenecyclohexylidene]ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]-2-methylheptane-2,3-diol
分子式 C27H44O3
分子量 416.64
溶解度 Soluble in DMSO
储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
24, 25-dihydroxyvitamin D3 [24,25(OH)2D3] is a Vitamin D (VD [1]) analogue that can inhibit some metabolic processes. It dose-dependently inhibited the intracellular 10-mM-Ca2+-evoked Ca2+-concentration-increase in enterocytes with an EC50 of 4.9 nM [2].
Vitamin D is important in calcium homeostasis, skeleton maintenance, and skeleton development. Two successive reactions are involved in the formation of VD: first the formation of 25-hydroxyvitamin D (25OHD); and second the formation of 1α, 25-dihydroxyvitamin D [1, 25(OH) 2D], the active hormonal vitamin D [3].
Ca2+ at 10 mM typically increased [Ca2+]i to a new stable value of 264 ± 16 nM from the basal value of 203 ± 13 nM. 24R, 25(OH)2D3 at concentrations from 0.2 pM to 202 nM dose-dependently inhibited the initial [Ca2+]i increase during the first 18 s (t= 300 to 318 s) and the final [Ca2+]i increase (t= 550 to 600 s), with EC50 values of 4.9 nM and 30 nM, respectively. 24R, 25(OH)2D3 at a concentration of 20 nM obtained the maximal inhibition (approximately 60%) to the Ca2+ uptake [2].
关键字： 40013-87-4;C27H44O3;24, 25-Dihydroxy VD3;
上海一研生物科技有限公司Shanghai yiyan bio-technology Co. Ltd.主要从事免疫学、分子生物学和常规生化试剂等为一体的科研产品销售企业，公司自成立以来，秉承""全心全意服务于科研工作者""的企业理念，立足生物科技领域，运用生物技术和科研试剂，发展现代生物科技，为各类大中小医院及其它医疗机构、高等院校、科研院所、企事业单位提供优质的产品，服务生物科技领域的科学研究人员。
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