产品属性:
产品名称
规格
CAS号
型号
4-hydroxy Atorvastatin lactone
1mg
163217-70-7
EY-Y0163573
Cas No.163217-70-7
别名 N/A
化学名 5-(4-fluorophenyl)-N-(4-hydroxyphenyl)-2-(1-methylethyl)-4-phenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide
分子式 C33H33FN2O5
分子量 556.6
溶解度 DMSO: Soluble,Methanol: Slightly soluble
储存条件 Store at -20°C General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. Shipping Condition Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request 产品描述: 4-hydroxy Atorvastatin lactone is a metabolite of atorvastatin , an HMG-CoA reductase inhibitor present in formulations that have been used to treat hypercholesterolemia and certain dyslipidemias. Atorvastatin is metabolized by the cytochrome P450 (CYP) isoform CYP3A4 to form 4-hydroxy atorvastatin and 2-hydroxy atorvastatin, which can be interconverted between their acid and lactone forms. Atorvastatin can itself be lactonized to atorvastatin lactone then metabolized by CYP3A4 directly to 4-hydroxy atorvastatin lactone and 2-hydroxy atorvastatin lactone.
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