产品属性:
产品名称 | 规格 | CAS号 | 型号 |
5-hydroxy Omeprazole | 500μg 1mg | 92340-57-3 | EY-Y0163623 |
Cas No.92340-57-3
别名 N/A
化学名 4-methoxy-6-[[(6-methoxy-1H-benzimidazol-2-yl)sulfinyl]methyl]-5-methyl-3-pyridinemethanol
分子式 C17H19N3O4S
![5-hydroxy Omeprazole.png 5-hydroxy Omeprazole.png](/SupplyImg/2022-11-22/6380471175606146496024733.jpg)
分子量 361.4
溶解度 10mg/mL in DMSO, 20mg/mL in DMF, 2mg/mL in Ethanol
储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述:
5-hydroxy Omeprazole is a major metabolite of omeprazole , an inhibitor of the gastric H+/K+-ATPase pump.[1] 5-hydroxy Omeprazole is produced from omeprazole by the action of cytochrome P450 (CYP) isoform 2C19, a monooxygenase. [2][3] CYP2C19 polymorphisms significantly influence the metabolism of omeprazole, and individuals may be classified as homozygous extensive metabolizers, heterozygous extensive metabolizers, and poor metabolizers.[1]
Reference:
[1]. Shi, S., and Klotz, U. Proton pump inhibitors: An update of their clinical use and pharmacokinetics. Eur. J. Clin. Pharmacol. 64(10), 935-951 (2008).
[2]. Abel?, A., Andersson, T.B., Antonsson, M., et al. Stereoselective metabolism of omeprazole by human cytochrome P450 enzymes. Drug Metab. Dispos. 28(8), 966-972 (2000).
[3]. Karam, W.G., Goldstein, J.A., Lasker, J.M., et al. Human CYP2C19 is a major omeprazole 5-hydroxylase, as demonstrated with recombinant cytochrome P450 enzymes. Drug Metab. Dispos. 24, 1081-1087 (1996).
关键字: 92340-57-3;C17H19N3O4S;5-hydroxy Omeprazole;
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