产品属性：
产品名称 | 规格 | CAS号 | 型号 |
Calcium D-Panthotenate | 25g 100g | 137-08-6 | EY-Y0163991 |
Cas No.137-08-6
别名
化学名
分子式 C18H32CaN2O10
分子量 476.53
溶解度 Soluble in DMSO
储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
Target: N/A
IC50: N/A
Calcium D-Panthotenate, also named vitamin B5 Calcium, is a water-soluble vitamin for many animals [1, 2]. Pantothenic acid participates in a number of intermediary metabolic reactions as a component of coenzyme A (CoA). It has been reported that pantothenic acid exhibits radioprotective and antioxidative effects and pantothenic acid has the potential to protect against cell damage produced by reactive oxygen species [3].
In vitro: Pantothenic acid (1 mM) increased biosynthesis of glutathione by boosting cell energetic in Jurkat cells [3]. In addition, pantothenic acid (1 mM) protected against oxidative damage and apoptosis in Ehrlich ascites tumour cells [4].
In vivo: Pantothenic acid (200 mg/kg, intraperitoneal injections) completely blocked valproic acid-induced neural tube defects and the decreases in c-Myb and Pim-1 protein expression in CD-1 mice [1]. Moreover, Calcium D-pantothenate (3.39-10.54 mg/kg, diets) increased the intestinal enzymes activities and docosahexaenoic acid (DHA) levels [2].
References:
1. Dawson JE, Raymond AM, Winn LM. Folic acid and pantothenic acid protection against valproic acid-induced neural tube defects in CD-1 mice. Toxicol Appl Pharmacol. 2006;211(2):124-32.
2. Qian Y, Li XF, Zhang DD, Cai DS, Tian HY, Liu WB. Effects of dietary pantothenic acid on growth, intestinal function, anti-oxidative status and fatty acids synthesis of juvenile blunt snout bream Megalobrama amblycephala. PLoS One. 2015;10(3):e0119518.
3. Slyshenkov VS, Dymkowska D, Wojtczak L. Pantothenic acid and pantothenol increase biosynthesis of glutathione by boosting cell energetics. FEBS Lett. 2004;569(1-3):169-72.
4. Wojtczak L, Slyshenkov VS. Protection by pantothenic acid against apoptosis and cell damage by oxygen free radicals--the role of glutathione. Biofactors. 2003;17(1-4):61-73.
关键字： 137-08-6;C18H32CaN2O10;Calcium D-Panthotena;
上海一研生物科技有限公司Shanghai yiyan bio-technology Co. Ltd.主要从事免疫学、分子生物学和常规生化试剂等为一体的科研产品销售企业，公司自成立以来，秉承""全心全意服务于科研工作者""的企业理念，立足生物科技领域，运用生物技术和科研试剂，发展现代生物科技，为各类大中小医院及其它医疗机构、高等院校、科研院所、企事业单位提供优质的产品，服务生物科技领域的科学研究人员。
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