产品属性:
产品名称
规格
CAS号
型号
Col003
5mg
328565-16-8
EY-Y0164092
Cas No.328565-16-8
别名 N/A
化学名 N/A
分子式 C14H11NO4
分子量 257.24
溶解度 DMSO: 25 mg/mL (97.19 mM)
储存条件 Store at -20°C General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. Shipping Condition Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request 产品描述: Col003 is a potent inhibitor of Hsp47, competitively binds to the collagen binding site on Hsp47 (IC50, 1.8 μM), and inhibits collagen secretion by destabilizing the collagen triple helix[1]. HSP47|1.8 μM (IC50)
[1]. Ito S, et al. A small-molecule compound inhibits a collagen-specific molecular chaperone and could represent a potential remedy for fibrosis. J Biol Chem. 2017 Dec 8;292(49):20076-20085.
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