产品属性：
产品名称 | 规格 | CAS号 | 型号 |
Gedunin | 1mg | 2753-30-2 | EY-Y0164153 |
Cas No.2753-30-2
别名
化学名 (1R,3aS,4aR,4bR,5S,6aS,10aR,10bS,12aS)-1-(furan-3-yl)-4b,7,7,10a,12a-pentamethyl-3,8-dioxo-1,3,3a,4b,5,6,6a,7,8,10a,10b,11,12,12a-tetradecahydronaphtho[2,1-f]oxireno[2,3-d]isochromen-5-yl acetate
分子式 C28H34O7
分子量 482.57
溶解度 Acetonitrile: 1 mg/ml,DMSO: 100 mM,Ethanol: 1 mg/ml,Methanol: 1 mg/ml
储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
Gedunin, a naturally occurring Hsp90 inhibitor, is tetranortriterpenoid isolated from the Indian neem tree (Azadirachta indica).
Hsp90 (heat shock protein 90) is a chaperone protein stabilizes proteins against heat stress, and aids in protein degradation. Originally, this protein was isolated by extracting proteins from cells stressed by heating, dehydrating or by other means. It also stabilizes a number of proteins required for tumor growth, thereby Hsp90 inhibitors are investigated as anti-cancer drugs.
In vitro, Gedunin induces degradation of Hsp90-dependent client protein and displays anti-proliferative activity in SKBr3, CaCo-2 and MCF-7 cancer cell lines with IC50 of 3.22, 16.8 and 8.84 μM respectively1.
Gedunin treatment was shown to exhibit anti-malarial activity against P. falciparum in parasite development and [3H]-hypoxanthine uptake assays with IC50 values of 0.14 and 3.1 μM respectively 2. Using mouse model, gedunin was demonstrated to present remarkable anti-inflammatory and anti-nociceptive effects on zymosan-induced inflamed knee joints, modulation of different cell populations3.
References:
1. Uddin SJ, Nahar L, Shilpi JA, et al. Gedunin, a limonoid from Xylocarpus granatum, inhibits the growth of CaCo-2 colon cancer cell line in vitro. Phytotherapy research : PTR. 2007;21(8):757-761.
2. Lee SE, Kim MR, Kim JH, et al. Antimalarial activity of anthothecol derived from Khaya anthotheca (Meliaceae). Phytomedicine : international journal of phytotherapy and phytopharmacology. 2008;15(6-7):533-535.
3. Conte FP, Ferraris FK, Costa TE, et al. Effect of gedunin on acute articular inflammation and hypernociception in mice. Molecules. 2015;20(2):2636-2657.
关键字： 2753-30-2;C28H34O7;Gedunin;
上海一研生物科技有限公司Shanghai yiyan bio-technology Co. Ltd.主要从事免疫学、分子生物学和常规生化试剂等为一体的科研产品销售企业，公司自成立以来，秉承""全心全意服务于科研工作者""的企业理念，立足生物科技领域，运用生物技术和科研试剂，发展现代生物科技，为各类大中小医院及其它医疗机构、高等院校、科研院所、企事业单位提供优质的产品，服务生物科技领域的科学研究人员。
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