别名
N-(3-氨基丙基)-2-[(3-甲基苯基)甲氧基]-N-(2-噻吩基甲基)-苯甲酰胺盐酸盐(1:1) 单盐酸半乙醇半水合物
应用
AMTB hydrate has been used as an inhibitor of transient receptor potential cation channel, subfamily melastatin, member 8 (TRPM8) in breast cancer cells and murine T cells.
生化/生理作用
AMTB是一种TRPM8选择性拮抗剂,与TRPV1或4没有交叉反应性。 icilin激活TRPM8的pIC50为6.23静脉注射给药AMTB,可以减少容量负荷膀胱的节律性收缩频率,并抑制血压和对膀胱扩张的内脏运动反射反应。 AMTB is a 2-benzyloxy-benzoic acid amide derivative, which also inhibits voltage-gated sodium channels (Nav) and their isoforms.
Sigma-Aldrich西格玛奥德里奇(上海)贸易有限公司
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