产品属性:
产品名称 | 规格 | CAS号 | 型号 |
Desethylchloroquine-d4 | 1 mg | 1189971-72-9 | EY-Y0164790 |
Cas No.1189971-72-9
别名 N/A
化学名 N/A
分子式 C16H18ClD4N3
![Desethylchloroquine-d4.png Desethylchloroquine-d4.png](/SupplyImg/2022-11-28/6380523593092451167040492.jpg)
分子量 295.8
溶解度 DMSO: slightly soluble,Methanol: slightly soluble
储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述:
Desethylchloroquine-d4 is intended for use as an internal standard for the quantification of desethylchloroquine by GC- or LC-MS. Desethylchloroquine is a major active metabolite of chloroquine .1 Desethylchloroquine is formed when chloroquine undergoes dealkylation, primarily by the cytochrome P450 (CYP) isoforms CYP2C8 and CYP3A4 and to a lesser extent by CYP2D6. It inhibits the growth of the P. falciparum strain LA136 in vitro (IC50 = 9.9 ng/ml).2
1.Projean, D., Baune, B., Farinotti, R., et al.In vitro metabolism of chloroquine: Identification of CYP2C8, CYP3A4, and CYP2D6 as the main isoforms catalyzing N-desethylchloroquine formationDrug Metab. Dispos.31(6)748-754(2003) 2.Aderounmu, F.A.In vitro assessment of the antimalarial activity of chloroquine and its major metabolitesAnn. Trop. Med. Parasitol.78(6)581-585(1984)
关键字: 1189971-72-9;C16H18ClD4N3;Desethylchloroquine-;
上海一研生物科技有限公司Shanghai yiyan bio-technology Co. Ltd.主要从事免疫学、分子生物学和常规生化试剂等为一体的科研产品销售企业,公司自成立以来,秉承""全心全意服务于科研工作者""的企业理念,立足生物科技领域,运用生物技术和科研试剂,发展现代生物科技,为各类大中小医院及其它医疗机构、高等院校、科研院所、企事业单位提供优质的产品,服务生物科技领域的科学研究人员。
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